Inverse relationship between gestational weight gain and glucose uptake in human placenta from female foetuses
Article first published online: 2 DEC 2013
© 2013 The Authors. Pediatric Obesity © 2013 International Association for the Study of Obesity
Volume 9, Issue 3, pages e73–e76, June 2014
How to Cite
Walker, S. P., Ugoni, A. M., Lim, R. and Lappas, M. (2014), Inverse relationship between gestational weight gain and glucose uptake in human placenta from female foetuses. Pediatric Obesity, 9: e73–e76. doi: 10.1111/j.2047-6310.2013.00206.x
- Issue published online: 13 MAY 2014
- Article first published online: 2 DEC 2013
- Manuscript Accepted: 14 OCT 2013
- Manuscript Received: 16 SEP 2013
- National Health and Medical Research Council (NHMRC) Career Development Award. Grant Number: 1047025
- NHMRC. Grant Number: 454310
- Austin Hospital Medical Research Foundation (AMRF)
- Foetal gender;
- glucose uptake;
- maternal gestational weight gain;
Maternal obesity and gestational weight gain (GWG) have a significant impact on the in utero environment, and thus on foetal development and the health of the offspring later in life.
The aim of this study was to determine the effect of maternal pre-existing obesity and maternal GWG on glucose uptake from placentas from male and female offspring.
Total glucose uptake was measured in placental explants using radio-labelled glucose.
In the female placentas (n = 36), GWG and glucose uptake were significantly negatively correlated (r = −0.7, P < 0.0001; n = 36), and customized birthweight centile correlated with placental glucose uptake (r = 0.36, P = 0.03) but not GWG. In the male placentas (n = 45), GWG and glucose uptake were not related, and customized birthweight centile correlated with GWG (r = 0.34, P = 0.02; n = 45), but not placental glucose uptake.
The female placenta can adapt glucose uptake in the face of excessive GWG. The male placenta showed no evidence of changing glucose uptake in response to maternal GWG.