Breast milk leptin and adiponectin in relation to infant body composition up to 2 years

Authors

  • S. Brunner,

    1. Else Kröner-Fresenius-Center for Nutritional Medicine, Klinikum rechts der Isar, Technische Universität München, Munich, Germany
    Search for more papers by this author
  • D. Schmid,

    1. Else Kröner-Fresenius-Center for Nutritional Medicine, Klinikum rechts der Isar, Technische Universität München, Munich, Germany
    Search for more papers by this author
  • K. Zang,

    1. Else Kröner-Fresenius-Center for Nutritional Medicine, Klinikum rechts der Isar, Technische Universität München, Munich, Germany
    Search for more papers by this author
  • D. Much,

    1. Else Kröner-Fresenius-Center for Nutritional Medicine, Klinikum rechts der Isar, Technische Universität München, Munich, Germany
    Search for more papers by this author
  • B. Knoeferl,

    1. Institute for Medical Statistics and Epidemiology, Klinikum rechts der Isar, Technische, Universität München, Munich, Germany
    Search for more papers by this author
  • J. Kratzsch,

    1. Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany
    Search for more papers by this author
  • U. Amann-Gassner,

    1. Else Kröner-Fresenius-Center for Nutritional Medicine, Klinikum rechts der Isar, Technische Universität München, Munich, Germany
    Search for more papers by this author
  • B. L. Bader,

    1. ZIEL – Research Center for Nutrition and Food Sciences, Nutritional Medicine Unit, Technische Universität München, Freising, Germany
    Search for more papers by this author
  • H. Hauner

    Corresponding author
    1. Else Kröner-Fresenius-Center for Nutritional Medicine, Klinikum rechts der Isar, Technische Universität München, Munich, Germany
    2. ZIEL – Research Center for Nutrition and Food Sciences, Nutritional Medicine Unit, Technische Universität München, Freising, Germany
    • Address for correspondence: Professor H Hauner, Else Kröner-Fresenius-Center for Nutritional Medicine, Klinikum rechts der Isar, Technische Universität München, Uptown München Campus D, Georg-Brauchle-Ring 60/62, München D-80992, Germany. E-mail: hans.hauner@tum.de

    Search for more papers by this author

Summary

Background

Adipokines in breast milk have been associated with infant growth trajectories.

Objective

We aimed to explore the relationship of leptin and adiponectin in breast milk with infant weight gain and body composition up to the age of 2 years.

Methods

Breast milk samples were collected from exclusively or partially breastfeeding mothers at 6 weeks (n = 152) and 4 months (n = 120) post-partum. Leptin and adiponectin were determined in skim breast milk and related to infant growth and fat mass assessed by skin-fold thickness measurements. A total of 118 infants were examined at 2 years.

Results

The levels of both milk adipokines were slightly lower at 4 months compared with 6 weeks post-partum. Breast milk leptin was largely unrelated to infant anthropometric measures up to 2 years. Milk adiponectin tended to be inversely related to early infant anthropometry up to 4 months, but beyond was positively associated with weight gain and the sum of skin-folds up to 2 years.

Conclusions

Our results suggest that higher adiponectin levels in breast milk might be associated with greater weight gain and higher fat mass in the offspring up to 2 years.

Ancillary