This work focused on the synthesis of high-activity strontium titanate (SrTiO3) photocatalysts through an environmentally friendly process. A high energy-efficient microwave-assisted hydrothermal method was employed to prepare Fe-loaded SrTiO3 that consisted of small particles around 50 nm in diameter. To achieve the effective assistance of long-lasting fluorescence, the obtained Fe-loaded SrTiO3 samples were coupled with CaAl2O4:(Eu, Nd). The photocatalytic activities were evaluated by the photo-decomposition of NO. Fe loaded SrTiO3 showed high photocatalytic activities not only under visible light irradiation but also in the dark with fluorescence assistance.