Anti-obesity effect of kimchi fermented with Weissella koreensis OK1-6 as starter in high-fat diet-induced obese C57BL/6J mice
Article first published online: 9 OCT 2012
© 2012 The Society for Applied Microbiology
Journal of Applied Microbiology
Volume 113, Issue 6, pages 1507–1516, December 2012
How to Cite
Park, J.-A., Tirupathi Pichiah, P.B., Yu, J.-J., Oh, S.-H., Daily, J.W. and Cha, Y.-S. (2012), Anti-obesity effect of kimchi fermented with Weissella koreensis OK1-6 as starter in high-fat diet-induced obese C57BL/6J mice. Journal of Applied Microbiology, 113: 1507–1516. doi: 10.1111/jam.12017
- Issue published online: 16 NOV 2012
- Article first published online: 9 OCT 2012
- Accepted manuscript online: 15 SEP 2012 06:07AM EST
- Manuscript Accepted: 9 SEP 2012
- Manuscript Revised: 8 SEP 2012
- Manuscript Received: 19 JUN 2012
- high-fat diet;
- Weissella koreensis OK1-6
In this study, we investigated the anti-obesity effects of kimchi (Korean traditional fermented vegetable) fermented either without starter culture or with a specific starter culture, Weissella koreensis OK1-6.
Methods and Results
C57BL/6J mice were divided into four groups (n = 7); normal diet, HF (high-fat diet), HF-KC (high-fat diet containing 3% kimchi manufactured without starter) and HF-KCO (high-fat diet containing 3% kimchi manufactured with the starter culture W. koreensis OK1-6). After 12 weeks of dietary intervention, the mice were killed, and serum and tissue samples were examined. Serum and hepatic lipid profile, insulin, leptin concentration and expression level of lipid anabolic genes like peroxisome proliferator-activated receptor γ, stearoyl-CoA desaturase-1, liver X receptor α and SREBP2 were significantly decreased (<0·05) along with body and epididymal fat pad weight in the HF-KCO group compared with the HF-KC and HF group.
These results suggested that kimchi fermented with the starter W. koreensis OK1-6 has anti-obesity effects in HF-induced obese mice.
Significance and Impact of the Study
These results may contribute to nutraceutical and food industries in developing functional food and probiotics based therapies for the treatment and prevention of obesity.