The antibiofilm effects of Byotrol™ G32
Article first published online: 1 MAR 2013
© 2013 The Society for Applied Microbiology
Journal of Applied Microbiology
Volume 114, Issue 5, pages 1285–1293, May 2013
How to Cite
Govindji, N., Wills, P., Upton, M., Tirelli, N., Yeates, S. and Webb, M. (2013), The antibiofilm effects of Byotrol™ G32. Journal of Applied Microbiology, 114: 1285–1293. doi: 10.1111/jam.12162
- Issue published online: 15 APR 2013
- Article first published online: 1 MAR 2013
- Accepted manuscript online: 8 FEB 2013 07:47AM EST
- Manuscript Accepted: 20 JAN 2013
- Manuscript Revised: 17 JAN 2013
- Manuscript Received: 19 OCT 2012
The purpose of this study was to evaluate a commercial antimicrobial formulation, Byotrol™ G32, as a potential coating for impeding biofilm formation on medical devices such as urinary catheters.
Methods and Results
The antimicrobial activity of Byotrol™ G32 and its individual constituents has been tested on planktonic and biofilm cultures of uropathogenic bacteria. The Byotrol™ G32 formulation was superior with MICs ranging from 3 μg ml−1 to 15 μg ml−1 for planktonic cultures and 3–20 μg ml−1 for biofilms. Furthermore, Byotrol™ G32 was able to remove established biofilms and act as an antibiofilm surface coating.
Byotrol™ G32 displays impressive antimicrobial activity both in suspension and as a coating. Pretreating medical devices with Byotrol™ G32 may significantly impede biofilm formation and prolong the lifetime of the device.
Significance and Impact of the study
Medical devices are indispensable in health care. They are, however, a predisposing factor in infection. This research has demonstrated that Byotrol™ G32 reduces bacterial growth and subsequent biofilm formation. Application of Byotrol™ G32 as a medical device coating could have a significant impact on the costs associated with device replacement and patient morbidity and mortality.