Immunotherapy of allergic diseases using probiotics or recombinant probiotics

Authors

  • M.S.P. de Azevedo,

    1. Laboratório de Genética Celular e Molecular, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (ICB/UFMG), Belo Horizonte, MG,, Brazil
    2. INRA, UMR1319 Micalis, Jouy-en-Josas, France
    3. AgroParisTech, UMR Micalis, Jouy-en-Josas, France
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    • These authors share the first authorship.
  • S. Innocentin,

    1. INRA, UMR1319 Micalis, Jouy-en-Josas, France
    2. AgroParisTech, UMR Micalis, Jouy-en-Josas, France
    3. Lymphocyte Signalling and Development Laboratory, Babraham Institute, Babraham Research Campus, Cambridge, UK
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    • These authors share the first authorship.
  • F.A. Dorella,

    1. Laboratório de Genética Celular e Molecular, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (ICB/UFMG), Belo Horizonte, MG,, Brazil
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  • C.S. Rocha,

    1. Laboratório de Genética Celular e Molecular, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (ICB/UFMG), Belo Horizonte, MG,, Brazil
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  • D. Mariat,

    1. INRA, UMR1319 Micalis, Jouy-en-Josas, France
    2. AgroParisTech, UMR Micalis, Jouy-en-Josas, France
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  • D.S. Pontes,

    1. Departamento de Ciências Biológicas, Universidade Estadual da Paraíba, Campus V, João Pessoa, PB,, Brazil
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  • A. Miyoshi,

    Corresponding author
    • Laboratório de Genética Celular e Molecular, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (ICB/UFMG), Belo Horizonte, MG,, Brazil
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  • V. Azevedo,

    1. Laboratório de Genética Celular e Molecular, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (ICB/UFMG), Belo Horizonte, MG,, Brazil
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  • P. Langella,

    1. INRA, UMR1319 Micalis, Jouy-en-Josas, France
    2. AgroParisTech, UMR Micalis, Jouy-en-Josas, France
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  • J.-M. Chatel

    Corresponding author
    1. INRA, UMR1319 Micalis, Jouy-en-Josas, France
    2. AgroParisTech, UMR Micalis, Jouy-en-Josas, France
    • Laboratório de Genética Celular e Molecular, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (ICB/UFMG), Belo Horizonte, MG,, Brazil
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Correspondence

Anderson Miyoshi, Instituto de Ciencias Biologicas (ICB), Universidade Federal de Minas Gerais (UFMG), Av. Antônio Carlos, 6627, Pampulha, Belo Horizonte, MG, CEP 31270-901, Brazil. E-mail: miyoshi@icb.ufmg.br

Jean-Marc Chatel, Institut National de la Recherche Agronomique (INRA), MICALIS, Domaine de Vilvert, Bat 440, R-2, 78352 Jouy-en-Josas Cedex, France.

E-mail: jean-marc.chatel@jouy.inra.fr

Summary

Allergic diseases affect up to 30% of the western population, and their prevalence is increasing. Probiotics are able to modulate the mucosal immune response, and clinical trials demonstrated that specific strains, especially lactic acid bacteria (LAB) ones, reduce allergic symptoms. Moreover, the use of recombinant probiotics has been evaluated as possible strategies for the immunotherapy of allergic diseases. The production and delivery of allergens by recombinant LAB in concert with their ability to induce a Th1-type immune response have been shown to be a promising mucosal vaccination strategy in mouse model. The aim of this article is to review the applications of probiotics in allergy immunotherapy with a special focus on recombinant LAB delivering proteins or DNA.

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