Novel antibacterial silver-silica surface coatings prepared by chemical vapour deposition for infection control
Article first published online: 13 AUG 2013
© 2013 The Society for Applied Microbiology
Journal of Applied Microbiology
Volume 115, Issue 5, pages 1107–1116, November 2013
How to Cite
Varghese, S., Elfakhri, S., Sheel, D.W., Sheel, P., Bolton, F.J. and Foster, H.A. (2013), Novel antibacterial silver-silica surface coatings prepared by chemical vapour deposition for infection control. Journal of Applied Microbiology, 115: 1107–1116. doi: 10.1111/jam.12308
- Issue published online: 15 OCT 2013
- Article first published online: 13 AUG 2013
- Accepted manuscript online: 21 JUL 2013 11:10PM EST
- Manuscript Revised: 15 JUL 2013
- Manuscript Accepted: 15 JUL 2013
- Manuscript Received: 28 FEB 2013
- CVD ;
Environmental contamination plays an important role in the transmission of infections, especially healthcare-associated infections. Disinfection transiently reduces contamination, but surfaces can rapidly become re-contaminated. Antimicrobial surfaces may partially overcome that limitation. The antimicrobial activity of novel surface coatings containing silver and silica prepared using a flame-assisted chemical vapour deposition method on both glass and ceramic tiles was investigated.
Methods and Results
Antimicrobial activity against a variety of bacteria including recent clinical isolates was investigated based on the BS ISO 22196:2007 Plastics – Measurement of antibacterial activity on plastics surfaces, British Standards Institute, London, method. Activity on natural contamination in an in use test in a toilet facility was also determined. Activity on standard test strains gave a log10 reduction of five after 1–4 h. The hospital isolates were more resistant, but MRSA was reduced by a log10 reduction factor of >5 after 24 h. Activity was maintained after simulated ageing and washing cycles. Contamination in situ was reduced by >99·9% after 4 months. Activity was inhibited by protein, but, although this could be overcome by increasing the amount of silver in the films, this reduced the hardness of the coating.
The coatings had a good activity against standard test strains. Clinical isolates were killed more slowly but were still sensitive. The optimum composition for use therefore needs to be a balance between activity and durability.
Significance and Impact of the Study
The coatings may have applications in health care by maintaining a background antimicrobial activity between standard cleaning and disinfection regimes. They may also have applications in other areas where reduction in microbial contamination is important, for example, in the food industry.