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Wild mushroom extracts potentiate the action of standard antibiotics against multiresistant bacteria

Authors

  • M.J. Alves,

    1. CBQF-Escola Superior de Biotecnologia, Universidade Católica Portuguesa Porto, Porto, Portugal
    2. Centro Hospitalar de Trás-os-Montes e Alto Douro- Unidade de Chaves, Chaves, Portugal
    3. ESA, Instituto Politécnico de Bragança, Centro de Investigação de Montanha (CIMO), Bragança, Portugal
    4. Escola Superior de Saúde, Instituto Politécnico de Bragança, Bragança, Portugal
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  • I.C.F.R. Ferreira,

    Corresponding author
    1. ESA, Instituto Politécnico de Bragança, Centro de Investigação de Montanha (CIMO), Bragança, Portugal
    • Correspondence

      Isabel C.F.R. Ferreira, ESA, Instituto Politécnico de Bragança, Centro de Investigação de Montanha (CIMO), Campus de Santa Apolónia, Apartado 1172, Bragança 5301-855, Portugal.E-mail: iferreira@ipb.pt

      Manuela Pintado, CBQF-Escola Superior de Biotecnologia, Universidade Católica Portuguesa Porto, Rua Dr. António Bernardino de Almeida, Porto 4200-072, Portugal. E-mail: mpintado@porto.ucp.pt

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  • I. Lourenço,

    1. Escola Superior de Saúde, Instituto Politécnico de Bragança, Bragança, Portugal
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  • A. Castro,

    1. Escola Superior de Saúde, Instituto Politécnico de Bragança, Bragança, Portugal
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  • L. Pereira,

    1. Escola Superior de Saúde, Instituto Politécnico de Bragança, Bragança, Portugal
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  • A. Martins,

    1. ESA, Instituto Politécnico de Bragança, Centro de Investigação de Montanha (CIMO), Bragança, Portugal
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  • M. Pintado

    Corresponding author
    1. CBQF-Escola Superior de Biotecnologia, Universidade Católica Portuguesa Porto, Porto, Portugal
    • Correspondence

      Isabel C.F.R. Ferreira, ESA, Instituto Politécnico de Bragança, Centro de Investigação de Montanha (CIMO), Campus de Santa Apolónia, Apartado 1172, Bragança 5301-855, Portugal.E-mail: iferreira@ipb.pt

      Manuela Pintado, CBQF-Escola Superior de Biotecnologia, Universidade Católica Portuguesa Porto, Rua Dr. António Bernardino de Almeida, Porto 4200-072, Portugal. E-mail: mpintado@porto.ucp.pt

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Abstract

Aims

The main objective of this study was to evaluate the capacity of wild mushroom extracts to potentiate the action of standard antibiotics, through synergisms that allow a decrease in their therapeutic doses and ultimately contribute to the reduction of resistances.

Methods and Results

Wild mushroom extracts were applied to different multiresistant micro-organisms (Escherichia coli, extended-spectrum beta-lactamase-producing (ESBL) E. coli and methicillin-resistant Staphylococcus aureus (MRSA), combined with commercial antibiotics (penicillin, ampicillin, amoxicillin/clavulanic acid, cefoxitin, ciprofloxacin, cotrimoxazol, levofloxacin). Microdilution method was used to determine minimum inhibitory concentrations (MICs). The results obtained showed higher synergistic effects against MRSA than against E. coli. Mycena rosea and Fistulina hepatica were the best extracts for synergistic effects against MRSA. The efficiency of Russula delica extract against E. coli 1 (resistant to ampicillin, ciprofloxacin and trimethoprim/sulfasoxazole) and E. coli 2 (resistant to amoxicillin/clavulanic acid and ampicillin) was higher than that of Leucopaxillus giganteus extract; nevertheless, the latter extract exhibited better synergistic effects against ESBL E. coli.

Conclusions

This study shows that, similarly to plants, some mushroom extracts can potentiate the action of antibiotics extensively used in clinical practice for Gram-positive or Gram-negative bacteria, with positive action even against multiresistant bacteria.

Significance and Impact of the Study

Mushroom extracts could decrease therapeutic doses of standard antibiotics and reduce micro-organism's resistance to those drugs.

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