Factors associated with gender differences in medication adherence: a longitudinal study
Article first published online: 10 FEB 2014
© 2014 John Wiley & Sons Ltd
Journal of Advanced Nursing
Volume 70, Issue 9, pages 2031–2040, September 2014
How to Cite
2014) Factors associated with gender differences in medication adherence: a longitudinal study. Journal of Advanced Nursing 70(9), 2031–2040. doi: 10.1111/jan.12361, , & (
- Issue published online: 11 AUG 2014
- Article first published online: 10 FEB 2014
- Manuscript Accepted: 11 JAN 2014
- Manuscript Revised: 21 NOV 2013
- Manuscript Received: 9 AUG 2013
- Taichung Veterans General Hospital
- Hungkuang University. Grant Number: TCVGHHK-968007
- blood pressure control;
- follow-up studies;
- illness perception;
- medication adherence;
To examine gender differences in the medication adherence of patients with hypertension by applying a longitudinal follow-up.
Patient views of illness affect their adherence to therapeutic regimens. However, few studies have explored these issues by using a longitudinal design or from a gender perspective.
This study used a longitudinal, correlational design.
A purposive sampling of 118 patients were recruited from cardiovascular clinics of a teaching hospital in Central Taiwan in 2007–2009. Data were collected using the Chinese Illness Perception Questionnaire-Revised and the Medication Adherence Inventory at three time points: at the first clinic visit, 6 and 12 months after the initial survey. Generalized estimating equations were calculated using the STATA software for data analysis.
The findings revealed that male patients adhere more effectively to medications than female patients do. The interaction between systolic blood pressure and gender emerged as a significant predictor of adherence. Factors associated with adherence in male patients included less causal attribution to culture, more attribution to risk factors, fewer symptoms and uncertain symptoms related to high blood pressure, lower scores for timeline-cyclical and higher scores for illness consequences and coherence. Medication adherence for female patients was significantly related to more causal attribution to balance and risk factors, less personal control and enhanced illness coherence.
Factors associated with adherence to antihypertensive medication were relatively gender-specific. Awareness of the differences is crucial for health professionals to provide appropriate advice for patients to cope effectively with their health threat.