Dr. Chik was supported by a Medical Research Scholarship from The Royal Australasian College of Physicians, Cardiac Society of Australia and New Zealand and The University of Sydney.
High Spatial Resolution Thermal Mapping of Radiofrequency Ablation Lesions Using a Novel Thermochromic Liquid Crystal Myocardial Phantom
Article first published online: 11 JUL 2013
© 2013 Wiley Periodicals, Inc.
Journal of Cardiovascular Electrophysiology
Volume 24, Issue 11, pages 1278–1286, November 2013
How to Cite
CHIK, W. W.B., BARRY, M. A., THAVAPALACHANDRAN, S., MIDEKIN, C., POULIOPOULOS, J., LIM, T. W., SIVAGANGABALAN, G., THOMAS, S. P., ROSS, D. L., McEWAN, A. L., KOVOOR, P. and THIAGALINGAM, A. (2013), High Spatial Resolution Thermal Mapping of Radiofrequency Ablation Lesions Using a Novel Thermochromic Liquid Crystal Myocardial Phantom. Journal of Cardiovascular Electrophysiology, 24: 1278–1286. doi: 10.1111/jce.12209
- Issue published online: 28 OCT 2013
- Article first published online: 11 JUL 2013
- Accepted manuscript online: 17 JUN 2013 01:35AM EST
- Manuscript Accepted: 6 MAY 2013
- Manuscript Revised: 29 APR 2013
- Manuscript Received: 13 NOV 2012
- Royal Australasian College of Physicians, Cardiac Society of Australia
- New Zealand and The University of Sydney
- catheter ablation;
- myocardial phantom;
- radiofrequency ablation;
High-Resolution Thermal Mapping of RF Ablation Lesions
Radiofrequency (RF) ablation causes thermal mediated irreversible myocardial necrosis. This study aimed to (i) characterize the thermal characteristics of RF ablation lesions with high spatial resolution using a thermochromic liquid crystal (TLC) myocardial phantom; and (ii) compare the thermochromic lesions with in vivo and in vitro ablation lesions.
Methods and Results
The myocardial phantom was constructed from a vertical sheet of TLC film, with color change between 50 °C (red) to 78 °C (black), embedded within a gel matrix, with impedance titrated to equal that of myocardium. Saline, with impedance titrated to blood values at 37 °C, was used as supernatant.
A total of 51 RF ablations were performed. This comprised 17 ablations in the thermochromic gel phantom, bovine myocardial in vitro targets and ovine in vivo ablations, respectively. There was no difference in lesion dimensions between the thermochromic gel and in vivo ablations (lesion width 10.2 ± 0.2 vs 10.2 ± 2.4, P = 0.93; and depth 6.3 ± 0.1 vs 6.5 ± 1.7, P = 0.74). The spatial resolution of the thermochromic film was tested using 2 thermal point-sources that were progressively opposed and was demonstrated to be <300 μm.
High spatial resolution thermal mapping of in vitro RF lesions with spatial resolution of at least 300 μm is possible using a thermochromic liquid crystal myocardial phantom model, with a good correlation to in vivo RF ablations. This model may be useful for assessing the thermal characteristics of RF lesions created using different ablation parameters and catheter technologies.