Is Isolated Systolic Hypertension Worse Than Combined Systolic/Diastolic Hypertension?

Authors

  • Yonggang Ma PhD,

    1. From the San Antonio Cardiovascular Proteomics Center;
    2. the Barshop Institute for Longevity and Aging Studies;
    3. the Division of Geriatrics, Gerontology and Palliative Medicine;
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  • Andriy Yabluchanskiy PhD,

    1. From the San Antonio Cardiovascular Proteomics Center;
    2. the Barshop Institute for Longevity and Aging Studies;
    3. the Division of Geriatrics, Gerontology and Palliative Medicine;
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  • Merry L. Lindsey PhD,

    1. From the San Antonio Cardiovascular Proteomics Center;
    2. the Barshop Institute for Longevity and Aging Studies;
    3. the Division of Geriatrics, Gerontology and Palliative Medicine;
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  • Robert J. Chilton MD

    1. From the San Antonio Cardiovascular Proteomics Center;
    2. and the Division of Cardiology, Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, TX
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Robert J. Chilton, MD, Division of Cardiology, Department of Medicine, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229
E-mail:chilton@uthscsa.edu

Abstract

J Clin Hypertens (Greenwich). 2012;14:808–809. ©2012 Wiley Periodicals, Inc.

New developments in cardiovascular translational sciences have significantly advanced our understanding of the endovascular biology of blood pressure. Reductions in vascular elasticity and vessel compliance of conduit arteries are key components of both ISH and SDH. Vascular changes from the matrix metalloproteinase family of enzymes are involved in arterial wall remodeling and vascular stiffness. This new translational information helps further our understanding of both ISH and SDH.

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