Association Between Antihypertensive Medication Adherence and Visit-to-Visit Variability of Blood Pressure
Article first published online: 28 NOV 2012
© 2012 Wiley Periodicals, Inc.
The Journal of Clinical Hypertension
Volume 15, Issue 2, pages 112–117, February 2013
How to Cite
Muntner, P., Levitan, E. B., Joyce, C., Holt, E., Mann, D., Oparil, S. and Krousel-Wood, M. (2013), Association Between Antihypertensive Medication Adherence and Visit-to-Visit Variability of Blood Pressure. The Journal of Clinical Hypertension, 15: 112–117. doi: 10.1111/jch.12037
- Issue published online: 22 JAN 2013
- Article first published online: 28 NOV 2012
- Manuscript received: July 23, 2012; revised: September 9, 2012; accepted: September 20, 2012
It has been hypothesized that high visit-to-visit variability (VVV) of systolic blood pressure (SBP) may be the result of poor antihypertensive medication adherence. The authors studied this association using data from 1391 individuals taking antihypertensive medication selected from a large managed care organization. The 8-item Morisky Medication Adherence Scale, administered during 3 annual surveys, captured self-report adherence, with scores <6, 6 to <8, and 8 representing low, medium. and high adherence, respectively. The mean (standard deviation [SD]) for SD of SBP across study visits was 12.9 (4.4), 13.5 (4.8), and 14.1 (4.5) mm Hg in participants with high, medium, and low self-reported adherence, respectively. After multivariable adjustment and compared with those with high self-report adherence, SD of SBP was 0.60 (95% confidence interval, 0.13–1.07) and 1.08 (95% confidence interval, 0.29–1.87) mm Hg higher among participants with medium and low self-report adherence, respectively. Results were consistent when pharmacy fill was used to define adherence. These data suggest that low antihypertensive medication adherence explains only a small proportion of VVV of SBP. J Clin Hypertens (Greenwich). 2012; 00:00–00. ©2012 Wiley Periodicals, Inc.