Hypertension in Pregnancy Is a Risk Factor for Microalbuminuria Later in Life
Article first published online: 29 APR 2013
©2013 Wiley Periodicals, Inc.
The Journal of Clinical Hypertension
Volume 15, Issue 9, pages 617–623, September 2013
How to Cite
J Clin Hypertens (Greenwich). 2013;15:617–623. ©2013 Wiley Periodicals, Inc.
- Issue published online: 3 SEP 2013
- Article first published online: 29 APR 2013
- Manuscript Revised: 20 MAR 2013
- Manuscript Accepted: 20 MAR 2013
- Manuscript Received: 24 JAN 2013
- National Institute on Aging
- Society for Women's Health Research (SWHR) ISIS Network
- National Heart, Lung, and Blood Institute, National Institutes of Health. Grant Numbers: U01HL054481, U01HL054471, U01HL054512, U01HL054498
The authors aimed to compare renal function by estimated glomerular filtration rate and albuminuria in 3 groups of women: nulliparous women, women with a history of normotensive pregnancies, and women with a history of at least one hypertensive pregnancy. Women who participated in the second Family Blood Pressure Program Study visit (2000–2004) and had serum creatinine and urine albumin measurements (n=3015) were categorized as having had no pregnancy lasting >6 months (n=341), having had only normotensive pregnancies (n=2199), or having had at least 1 pregnancy with hypertension (n=475) based on a standardized questionnaire. Women who reported having had at least one pregnancy with hypertension were significantly more likely to be hypertensive (75.6% vs 59.4%, P<.001), diabetic (34.2% vs 27.3%, P≤.001), and have higher body mass index (32.8 vs 30.5, P<.001) than those who reported normotensive pregnancies. There was a significantly greater risk of microalbuminuria (urine albumin-creatinine ratio >25 mg/g) in those who reported at least one pregnancy with hypertension (odds ratio, 1.37; confidence interval, 1.02–1.85; P=.04) than in those with normotensive pregnancies, after adjusting for risk factors for chronic kidney and cardiovascular disease. Hypertension in pregnancy is associated with an increased risk of future microalbuminuria.