Mr Carotta and Mrs Carzaniga took part in all of the technical phases of the study as scientificic technicians of the Università degli Studi di Milano, Milan, Italy.
Increased Aortic Stiffness and Related Factors in Patients With Peripheral Arterial Disease
Article first published online: 16 JUL 2013
©2013 Wiley Periodicals, Inc.
The Journal of Clinical Hypertension
Volume 15, Issue 10, pages 712–716, October 2013
How to Cite
J Clin Hypertens (Greenwich). 2013;15:712–716. ©2013 Wiley Periodicals, Inc.
- Issue published online: 1 OCT 2013
- Article first published online: 16 JUL 2013
- Manuscript Accepted: 9 JUN 2013
- Manuscript Revised: 4 JUN 2013
- Manuscript Received: 12 APR 2013
A number of conditions have been associated with functional changes of large arteries. The aim of this study was to evaluate the factors associated with aortic stiffness in patients with peripheral arterial disease (PAD). The authors studied 86 patients with PAD (ankle-brachial pressure index [ABPI] ≤0.9) and 86 controls. Aortic stiffness was determined by pulse wave velocity (aPWV) using applanation tonometry. In PAD patients, aPWV was higher compared with controls (11±3 vs 9.8±1.8; P=.002). In multiple regression analysis, aPWV was independently associated with pulse pressure (β=0.05, P=.01) in the PAD patients and with age in the control group (β=0.08, P=.0005). The results of this study confirm an aPWV increase in patients with PAD and emphasize the association between blood pressure and aPWV. Further studies are necessary to assess whether higher aortic stiffening adds prognostic value to ABPI, which is the most powerful prognostic indicator in PAD.