Increased Aortic Stiffness and Related Factors in Patients With Peripheral Arterial Disease

Authors

  • Mariella Catalano MD,

    Corresponding author
    • Research Center on Vascular Diseases and Angiology Unit, University of Milan, Milan, Italy
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  • Giovanni Scandale MD,

    1. Research Center on Vascular Diseases and Angiology Unit, University of Milan, Milan, Italy
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  • Gianni Carzaniga,

    1. Research Center on Vascular Diseases and Angiology Unit, University of Milan, Milan, Italy
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    • Mr Carotta and Mrs Carzaniga took part in all of the technical phases of the study as scientificic technicians of the Università degli Studi di Milano, Milan, Italy.

  • Michela Cinquini BSc,

    1. Laboratory for the Development of New Pharmacological Strategies Department of Oncology, Mario Negri Institute for Pharmacological Research, Milan, Italy
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  • Marzio Minola MD,

    1. Research Center on Vascular Diseases and Angiology Unit, University of Milan, Milan, Italy
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  • Gabriel Dimitrov MD,

    1. Research Center on Vascular Diseases and Angiology Unit, University of Milan, Milan, Italy
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  • Maria Carotta

    1. Research Center on Vascular Diseases and Angiology Unit, University of Milan, Milan, Italy
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    • Mr Carotta and Mrs Carzaniga took part in all of the technical phases of the study as scientificic technicians of the Università degli Studi di Milano, Milan, Italy.


Address for correspondence: Mariella Catalano, MD, Angiology Unit, Research Center on Vascular Diseases, University of Milan, L. Sacco Hospital, Via GB Grassi, 74 I-20157 Milan, Italy

E-mail: mariella.catalano@unimi.it

Abstract

A number of conditions have been associated with functional changes of large arteries. The aim of this study was to evaluate the factors associated with aortic stiffness in patients with peripheral arterial disease (PAD). The authors studied 86 patients with PAD (ankle-brachial pressure index [ABPI] ≤0.9) and 86 controls. Aortic stiffness was determined by pulse wave velocity (aPWV) using applanation tonometry. In PAD patients, aPWV was higher compared with controls (11±3 vs 9.8±1.8; P=.002). In multiple regression analysis, aPWV was independently associated with pulse pressure (β=0.05, P=.01) in the PAD patients and with age in the control group (β=0.08, P=.0005). The results of this study confirm an aPWV increase in patients with PAD and emphasize the association between blood pressure and aPWV. Further studies are necessary to assess whether higher aortic stiffening adds prognostic value to ABPI, which is the most powerful prognostic indicator in PAD.

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