Relationship Between Inter-Arm Difference in Systolic Blood Pressure and Arterial Stiffness in Community-Dwelling Older Adults
Version of Record online: 7 AUG 2013
Published 2013. This article is a U.S. Government work and is in the public domain in the USA.
The Journal of Clinical Hypertension
Volume 15, Issue 12, pages 880–887, December 2013
How to Cite
J Clin Hypertens (Greenwich). 2013;15:880–887. DOI: 10.1111/jch.12178. ©2013 Wiley Periodicals, Inc.
- Issue online: 3 DEC 2013
- Version of Record online: 7 AUG 2013
- Manuscript Accepted: 7 JUL 2013
- Manuscript Revised: 2 JUL 2013
- Manuscript Received: 7 MAY 2013
- Intramural Research Program of the NIH
- National Institute on Aging
A significant inter-arm difference in systolic blood pressure (IADSBP) has recently been associated with worse cardiovascular outcomes. The authors hypothesized that part of this association is mediated by arterial stiffness, and examined the relationship between significant IADSBP and carotid-femoral pulse wave velocity (CF-PWV) in a sample from the Baltimore Longitudinal Study of Aging. Of 1045 participants, 50 (4.8%) had an IADSBP ≥10 mm Hg at baseline, and 629 had completed data from ≥2 visits (for a total of 1704 visits during 8 years). CF-PWV was significantly higher in patients with an IADSBP ≥10 mm Hg (7.3±1.9 vs 8.2±2, P=.002). Compared with others, patients with IADSBP ≥10 mm Hg also had higher body mass index, waist circumference, and triglycerides; higher prevalence of diabetes; and lower high-density lipoprotein (HDL) cholesterol (P<.001 for all). A significant association with IADSBP ≥10 mm Hg was observed for CF-PWV in both cross-sectional (odds ratio [OR], 1.19; 95% confidence interval [CI], 1.06–1.87; P=.01) and longitudinal (OR, 1.15; 95% CI, 1.03–1.29; P=.01) multivariate analyses. Female sex, Caucasian race, high body mass index (plus diabetes and low HDL cholesterol only cross-sectionally) were other independent correlates of IADSBP ≥10 mm Hg. Significant IADSBP is associated with increased arterial stiffness in community-dwelling older adults.