• 1
    Houston MC. Treatment of hypertension with nutraceuticals. vitamins, antioxidants and minerals. Expert Rev Cardiovasc Ther. 2007;5:681691.
  • 2
    Eaton SB, Eaton SB III, Konner MJ. Paleolithic nutrition revisited: a twelve-year retrospective on its nature and implications. Eur J Clin Nutr. 1997;51:207216.
  • 3
    Houston MC, Harper KJ. Potassium, magnesium, and calcium: their role in both the cause and treatment of hypertension. J Clin Hypertens (Greenwich). 2008;10(7 suppl 2):311.
  • 4
    Layne J, Majkova Z, Smart EJ, et al. Caveolae: a regulatory platform for nutritional modulation of inflammatory diseases. J Nutr Biochem. 2011;22:807811.
  • 5
    Dandona P, Ghanim H, Chaudhuri A, et al. Macronutrient intake induces oxidative and inflammatory stress: potential relevance to atherosclerosis and insulin resistance. Exp Mol Med. 2010;42:245253.
  • 6
    Berdanier CD. Nutrient-gene Interactions. In: Ziegler EE, Filer LJ Jr, eds. Present Knowledge in Nutrition, 7th ed. Washington, DC: ILSI Press;1996:574580.
  • 7
    Talmud PJ, Waterworth DM. In-vivo and in-vitro nutrient-gene interactions. Curr Opin Lipidol. 2000;11:3136.
  • 8
    Lundberg AM, Yan ZQ. Innate immune recognition receptors and damage-associated molecular patterns in plaque inflammation. Curr Opin Lipidol. October 2011;22:343349.
  • 9
    Zhao L, Lee JY, Hwang DH. Inhibition of pattern recognition receptor-mediated inflammation by bioactive phytochemicals. Nutr Rev. 2011;69:310320.
  • 10
    Houston MC. The importance of potassium in managing hypertension. Curr Hypertens Rep. 2011;13:309317.
  • 11
    Eftekhari A, Mathiassen ON, Buus NH, et al. Disproportionally impaired microvascular structure in essential hypertension. J Hypertens. 2011;29:896905.
  • 12
    Touyz RM. New insights into mechanisms of hypertension. Curr Opin Nephrol Hypertens. 2012;21:119121.
  • 13
    Xing T, Wang F, Li J, Wang N. Hypertension: an immunologic disease? J Hypertens. 2012;30:24402441.
  • 14
    Giannattasio C, Cattaneo BM, Mangoni AA, et al. Cardiac and vascular structural changes in normotensive subjects with parental hypertension. J Hypertens. 1995;13:259264.
  • 15
    Goncharov A, Bloom M, Pavuk M, et al. Blood pressure and hypertension in relation to levels of serum polychlorinated biphenyls in residents of Anniston, Alabama. J Hypertens. 2010;28:20532060.
  • 16
    Houston MC. Role of mercury toxicity in hypertension, cardiovascular disease, and stroke. J Clin Hypertens (Greenwich). 2011;13:621627.
  • 17
    Al-Ghamdi A. Role of herpes simplex virus-1, cytomegalovirus and Epstein-Barr virus in atherosclerosis. Pak J Pharm Sci. January 2012;25:8997.
  • 18
    Kotronias D, Kapranos N. Herpes simplex virus as a determinant risk factor for coronary artery atherosclerosis and myocardial infarction. In Vivo. 2005;19:351357.
  • 19
    Grahame-Clarke C, Chan NN, Andrew D, et al. Human cytomegalovirus seropositivity is associated with impaired vascular function. Circulation. 2003;108:678683. Epub 2003 Aug 4.
  • 20
    Nayak DU, Karmen C, Frishman WH, Vakili BA. Antioxidant vitamins and enzymatic and synthetic oxygen-derived free radical scavengers in the prevention and treatment of cardiovascular disease. Heart Dis. 2001;3:2845.
  • 21
    Kizhakekuttu TJ, Widlansky ME. Natural antioxidants and hypertension: promise and challenges. Cardiovasc Ther. 2010;28:e20e32.
  • 22
    Kitiyakara C, Wilcox C. Antioxidants for hypertension. Curr Opin Nephrol Hypertens. 1998;7:531538.
  • 23
    Russo C, Olivieri O, Girelli D, et al. Antioxidant status and lipid peroxidation in patients with essential hypertension. J Hypertens. 1998;16:12671271.
  • 24
    Tse WY, Maxwell SR, Thomason H, et al. Antioxidant status in controlled and uncontrolled hypertension and its relationship to endothelial damage. J Hum Hypertens. 1994;8:843849.
  • 25
    Mansego ML, Solar Gde M, Alonso MP, et al. Polymorphisms of antioxidant enzymes, blood pressure and risk of hypertension. J Hypertens. 2011;29:492500.
  • 26
    Galley HF, Thornton J, Howdle PD, et al. Combination oral antioxidant supplementation reduces blood pressure. Clin Sci. 1997;92:361365.
  • 27
    Broadhurst CL. Balanced intakes of natural triglycerides for optimum nutrition: an evolutionary and phytochemical perspective. Med Hypotheses. 1997;49:247261.
  • 28
    Dhalla NS, Temsah RM, Netticadam T. The role of oxidative stress in cardiovascular diseases. J Hypertens. 2000;18:655673.
  • 29
    Saez G, Tormos MC, Giner V, et al. Oxidative stress and enzymatic antioxidant mechanisms in essential hypertension. Am J Hypertens. 2001;14:248A. Abstract P-653.
  • 30
    Nishihara M, Hirooka Y, Matsukawa R, et al. Oxidative stress in the rostral ventrolateral medulla modulates excitatory and inhibitory inputs in spontaneously hypertensive rats. J Hypertens. 2012;30:97106.
  • 31
    Konno S, Hirooka Y, Kishi T, Sunagawa K. Sympathoinhibitory effects of telmisartan through the reduction of oxidative stress in the rostral ventrolateral medulla of obesity-induced hypertensive rats. J Hypertens. 2012;30:19921999.
  • 32
    Ghanem FA, Movahed A. Inflammation in high blood pressure: a clinician perspective. J Am Soc Hypertens. 2007;1:113119.
  • 33
    Amer MS, Elawam AE, Khater MS, et al. Association of high-sensitivity C reactive protein with carotid artery intima-media thickness in hypertensive older adults. J Am Soc Hypertens. April 2011;5:395400.
  • 34
    Vongpatanasin W, Thomas GD, Schwartz R, et al. C-reactive protein causes downregulation of vascular angiotensin subtype 2 receptors and systolic hypertension in mice. Circulation. 2007;115:10201028.
  • 35
    Razzouk L, Munter P, Bansilal S, et al. C reactive protein predicts long-term mortality independently of low-density lipoprotein cholesterol in patients undergoing percutaneous coronary intervention. Am Heart J. 2009;158:277283.
  • 36
    Kvakan H, Luft FC, Muller DN. Role of the immune system in hypertensive target organ damage. Trends Cardiovasc Med. 2009;19:242246.
  • 37
    Rodriquez-Iturbe B, Franco M, Tapia E, et al. Renal inflammation, autoimmunity and salt-sensitive hypertension. Clin Exp Pharmacol Physiol. 2012;39:96103.
  • 38
    Tian N, Penman AD, Mawson AR, et al. Association between circulating specific leukocyte types and blood pressure The Atherosclerosis risk in communities(ARIC) study. J Am Soc Hypertens. 2010;4:272283.
  • 39
    Muller DN, Kvakan H, Luft FC. Immune-related effects in hypertension on and target-organ damage. Curr Opin Nephrol Hypertens. 2011;20:113117.
  • 40
    Marketou ME, Kontaraki JE, Zacharis EA, et al. TLR2 and TLR4 gene expression in peripheral monocytes in nondiabetic hypertensive patients: the effect of intensive blood pressure-lowering. J Clin Hypertens (Greenwich). 2012;14:330335.
  • 41
    Luft FC. Neural regulation of the immune system modulates hypertension-induced target-organ damage. J Am Soc Hypertens. 2012;6:2326.
  • 42
    Herrada AA, Campino C, Amador CA, et al. Aldosterone as a modulator of immunity: implications in the organ damage. J Hypertens. 2011;29:16841692.
  • 43
    Colussi G, Catena C, Sechi LA. Spironolactone, eplerenone and the new aldosterone blockers in endocrine and primary hypertension. J Hypertens. January 2013;31:315.
  • 44
    Appel LJ, Moore TJ, Obarzanek E, et al; Research Group. A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative. N Engl J Med. April 1997;336:11171124.
  • 45
    Sacks FM, Svetkey LP, Vollmer WM, et al; DASH-Sodium Collaborative Research Group. Effects on blood pressure of reduced dietary sodium and the Dietary Approaches to Stop Hypertension (DASH) diet. DASH-Sodium Collaborative Research Group. N Engl J Med. January 2001;344:310
  • 46
    Sun B, Williams JS, Svetkey LP, et al. Beta2-adrenergic receptor genotype affects the renin-angiotensin-aldosterone system response to the Dietary Approaches to Stop Hypertension (DASH) dietary pattern. Am J Clin Nutr. 2010;92:444449.
  • 47
    Chen Q, Turban S, Miller ER, Appel LJ. The effects of dietary patterns on plasma renin activity: results from the Dietary Approaches to Stop Hypertension trial. J Hum Hypertens. 2012;26:664669.
  • 48
    Al-Solaiman Y, Jesri A, Zhao Y, et al. Low-sodium DASH reduces oxidative stress and improves vascular function in salt-sensitive humans. J Hum Hypertens. 2009;23:826835.
  • 49
    Lin PH, Allen JD, Li YJ, et al. Blood pressure-lowering mechanisms of the DASH dietary pattern. J Nutr Metab. 2012;2012:472396.