Nutrition and Nutraceutical Supplements for the Treatment of Hypertension: Part III
Version of Record online: 1 OCT 2013
©2013 Wiley Periodicals, Inc.
The Journal of Clinical Hypertension
Volume 15, Issue 12, pages 931–937, December 2013
How to Cite
J Clin Hypertens (Greenwich). 2013;15:931–937. DOI: 10.1111/jch.12211. ©2013 Wiley Periodicals, Inc.
- Issue online: 3 DEC 2013
- Version of Record online: 1 OCT 2013
- Manuscript Accepted: 28 AUG 2013
- Manuscript Revised: 26 AUG 2013
- Manuscript Received: 22 APR 2013
Vascular biology, endothelial and vascular smooth muscle, and cardiac dysfunction play a primary role in the initiation and perpetuation of hypertension, cardiovascular disease, and target organ damage. Nutrient-gene interactions and epigenetics are predominant factors in promoting beneficial or detrimental effects in cardiovascular health and hypertension. Macronutrients and micronutrients can prevent, control, and treat hypertension through numerous mechanisms related to vascular biology. Oxidative stress, inflammation, and autoimmune dysfunction initiate and propagate hypertension and cardiovascular disease. There is a role for the selected use of single and component nutraceutical supplements, vitamins, antioxidants, and minerals in the treatment of hypertension based on scientifically controlled studies that complement optimal nutrition, coupled with other lifestyle modifications.