Are There Height-Dependent Differences in Subclinical Vascular Disease in Hypertensive Patients?
Article first published online: 5 NOV 2013
©2013 Wiley Periodicals, Inc.
The Journal of Clinical Hypertension
Volume 16, Issue 1, pages 70–76, January 2014
How to Cite
J Clin Hypertens (Greenwich). 2014;16:70–76. ©2013 Wiley Periodicals, Inc.
- Issue published online: 11 JAN 2014
- Article first published online: 5 NOV 2013
- Manuscript Accepted: 27 SEP 2013
- Manuscript Revised: 20 SEP 2013
- Manuscript Received: 16 AUG 2013
- Fondo de Investigacion Sanitaria. Grant Numbers: 07/0140, ETES 08/90539
- Health Care Research Foundation
- Ministry of Health, Spain
The aim of the study was to determine whether there are differences in subclinical vascular disease (SVD) in hypertensive patients in relation to height. A total of 922 hypertensive, newly diagnosed, treatment-naive patients were included. Physical examination was conducted, with renal function, electrocardiography, and retinography. Patients were distributed according to quartiles of height and sex. Multivariate analysis adjusted for age, sex, and body mass index showed an association between height above the mean and fasting glucose (odds ratio [OR], 1.04; 95% confidence interval [CI], 1.02–1.06), high-density lipoprotein cholesterol (OR, 0.96; CI, 0.92–0.99), triglycerides (OR, 1.07; CI, 1.01–1.15), and left ventricular hypertrophy (LVH) (OR, 1.57; CI, 1.10–2.24). The authors found an inverse association between arteriole-to-venule ratio and height above the mean (OR, 0.97; CI, 0.94–0.99). There are differences in the SVD of hypertensive patients in relation to height. Tall stature is associated with LVH while short stature is associated with increased microvascular involvement. Detection of SVD in hypertensive patients should consider the height.