The Age-Related Hemodynamic Changes of Blood Pressure and Their Impact on the Incidence of Cardiovascular Disease and Stroke: New Evidence
Article first published online: 27 DEC 2013
©2013 Wiley Periodicals, Inc.
The Journal of Clinical Hypertension
Volume 16, Issue 2, pages 87–90, February 2014
How to Cite
J Clin Hypertens (Greenwich). 2014;16:87–90. DOI: 10.1111/jch.12253. ©2013 Wiley Periodicals, Inc.
- Issue published online: 13 FEB 2014
- Article first published online: 27 DEC 2013
- Manuscript Accepted: 29 NOV 2013
- Manuscript Received: 11 NOV 2013
There is a linear change in blood pressure (BP) with the advancement of age from predominantly diastolic BP (DBP) in the young to predominantly systolic BP (SBP) in the old. This change is caused by the stiffening of the large arteries and the loss of elastic recoil as a result of replacement of the elastic fibers with collagen fibers. The result of this ageing process leads to an increase in pulse wave velocity and widening of pulse pressure. These hemodynamic changes are associated with an increased incidence in cardiovascular diseases (CVDs) and strokes. Recently, an inverse relationship with stroke risk was noted when the DBP was <71 mm Hg in persons older than 60 years. Accordingly, when treating SBP in the elderly, care should be taken not to lower the DBP below this level in order to minimize the risk for CVD and stoke.