Association of Serum Osteoprotegerin Levels With Carotid-Femoral Pulse Wave Velocity in Hypertensive Patients
Article first published online: 19 MAR 2014
©2014 Wiley Periodicals, Inc.
The Journal of Clinical Hypertension
Volume 16, Issue 4, pages 301–308, April 2014
How to Cite
J Clin Hypertens (Greenwich). 2014;00:301–308. DOI: 10.1111/jch.12288. © 2014 Wiley Periodicals, Inc.
- Issue published online: 16 APR 2014
- Article first published online: 19 MAR 2014
- Manuscript Accepted: 16 JAN 2014
- Manuscript Revised: 7 JAN 2014
- Manuscript Received: 17 NOV 2013
Osteoprotegerin (OPG) has been implicated in the process of vascular stiffness. The aim of this study was to evaluate the relationship between fasting serum OPG concentration and carotid-femoral pulse wave velocity (c-f PWV) in hypertensive patients. Fasting blood samples were obtained from 184 participants with or without hypertension. c-f PWV were performed by SphygmoCor system. Serum OPG levels were measured using a commercially available enzyme-linked immunosorbent assay. Hypertensive patients who had diabetes had higher c-f PWV levels than those without diabetes (P=.031). The univariable linear regression analysis showed that age (P<.001), systolic blood pressure (P=.003), pulse pressure (r=0.287; P=.003), log-BUN (P=.011), Cre (P<.001), and log-OPG concentration (P<.001) were positively correlated with c-f PWV levels, while the glomerular filtration rate (P=.005) and HDL-C level (P=.024) was negatively correlated with c-f PWV levels among the hypertensive patients. Multivariable forward stepwise linear regression analysis of the significant variables also showed that log-OPG (β=0.312, regression coefficient: 1.736; 95% confidence interval, 0.809–2.663; P<.001) was still an independent predictor of c-f PWV levels in hypertensive patients. Serum OPG levels positively associated with c-f PWV levels in hypertensive patients.