• 1
    Eglen RM. Muscarinic receptor subtype pharmacology and physiology. Prog Med Chem. 2005; 43: 10536.
  • 2
    Cohen RI, Molina-Holgado E, Almazan G. Carbachol stimulates c-fos expression and proliferation in oligodendrocyte progenitors. Mol Brain Res. 1996; 43: 193201.
  • 3
    Larocca JN, Alzman G. Acetylcholine agonists stimulate mitogen-activated protein kinase in oligodendrocyte progenitors by muscarinic receptors. J Neurosci. 1997; 50: 74354.
  • 4
    Loreti S, Ricordy R, De Stefano ME, et al. Acetylcholine inhibits cell cycle progression in rat Schwann cells by activation of the M2 receptor subtype. Neuron Glia Biol. 2007; 3: 26979.
  • 5
    Ragheb F, Molina-Holgado E, Cui Q, et al. Pharmacological and functional characterization of muscarinic receptor subtypes in developing oligodendrocytes. J Neurochem. 2001; 77: 1396406.
  • 6
    De Angelis F, Bernardo A, Magnaghi V, et al. Muscarinic receptor subtypes as potential targets to modulate oligodendrocyte progenitor survival, proliferation and differentiation. Develop Neurobiol. 2012; 72: 71328.
  • 7
    Loreti S, Vilarò MT, Visentin S, et al. Rat Schwann Cells express M1–M4 muscarinic receptor subtypes. J Neurosci Res. 2006; 84: 97105.
  • 8
    Ma W, Li BS, Zhang L, et al. Signaling cascades implicated in muscarinic regulation of proliferation of neural stem and progenitor cells. Drug News Perspect. 2004; 17: 25866.
  • 9
    Zhou C, Wen ZX, Shi DM, et al. Muscarinic acetylcholine receptors involved in the regulation of neural stem cell proliferation and differentiation in vitro. Cell Biol Inter. 2004; 28: 637.
  • 10
    Felder CC, Baymaster FP, Ward J, et al. Therapeutic opportunities for muscarinic receptors in the central nervous system. J Med Chem. 2000; 43: 433353.
  • 11
    Wang H, NG K, Hayes D, et al. Decreased amphetamine-induced locomotion and improved latent inhibition in mice mutant for the M5 muscarinic receptor gene found in human 15q schizophrenia region. Neuropsychopharmacol. 2005; 29: 212639.
  • 12
    Tata AM. Muscarinic Acetylcholine receptors: new potential therapeutic targets in antinociception and in cancer therapy. Rec Patents in CNS Drug Discov. 2008; 3: 110.
  • 13
    Hulme HC, Birdsall NJM, Buckley NJ. Muscarinic receptor subtypes. Ann Rev Pharmacol Toxicol. 1990; 30: 63373.
  • 14
    Cui QL, Fogle E, Almazan G. Muscarinic acetylcholine receptors mediate survival through Src-like tyrosine kinase and PI3K/AKT pathways. Neurochem Int. 2006; 48: 38393.
  • 15
    Williams CL, Lennon A. Activation of muscarinic acetylcholine receptors inhibits cell cycle progression of small cell lung carcinoma. Cell Regulation. 1991; 2: 37381.
  • 16
    Rayford W, Noble MJ, Austenfeld MA, et al. Muscarinic cholinergic receptors promote growth of human prostate cancer cells. Prostate. 1997; 30: 1606.
  • 17
    Frucht H, Jensen RT, Dexter D, et al. Human colon cancer cell proliferation mediated by the M3 muscarinic cholinergic receptor. Clinical Cancer Res. 1999; 5: 25329.
  • 18
    Oppitz M, Möbus V, Brock S, et al. Muscarinic receptors in cell lines from ovarian carcinoma: negative correlation with survival of patients. Gynecologic Oncol. 2002; 85: 15964.
  • 19
    Song P, Sekhon HS, Lu A, et al. M3 muscarinic receptor antagonists inhibit small cell lung carcinoma growth and mitogen-activated protein kinase phosphorylation induced by acetylcholine secretion. Cancer Res. 2007; 67: 393644.
  • 20
    Boss A, Oppitz M, Drews U. Muscarinic cholinergic receptors in the human melanoma cell line SK-Mel 28: modulation of chemotaxis. Clin Exp Dermatol. 2005; 30: 55764.
  • 21
    Rimmaudo LE, De La Torre E, Sacerdote de Lustig E, et al. Muscarinic receptors are involved in LMM3 tumor cells proliferation and angiogenesis. Bioch Bioph Res Com. 2005; 334: 135964.
  • 22
    Jiménez E, Montiel M. Activation of MAP kinase by muscarinic cholinergic receptors induces cell proliferation and protein synthesis in human breast cancer cells. J Cell Physiol. 2005; 204: 67886.
  • 23
    Oppitz M, Busch G, Garbe C, et al. Distribution of muscarinic receptor subtype M3 in melanomas and their metastases. J Cutan Pathol. 2008; 35: 80915.
  • 24
    Song P, Harmanjatider S, Sekhon S, et al. Acetylcholine is synthesized by and acts as an autocrine growth factor for small cell lung carcinoma. Cancer Res. 2003; 63: 21421.
  • 25
    Murphy S, Pearce B, Morrow C. Astrocytes have both M1 and M2 muscarinic receptor subtypes. Brain Res. 1986; 364: 17780.
  • 26
    Guizzetti M, Costa P, Peters J, et al. Acetylcholine as a mitogen: muscarinic receptor-mediated proliferation of rat astrocytes and human astrocytoma cells. Europ J Pharmacol. 1996; 297: 26573.
  • 27
    Tata AM, Calogero A. Muscarinic receptors and cancer: possible implications in tumors of the nervous system. Curr Trends in Neurol. 2010; 4: 2331.
  • 28
    Ferretti M, Fabbiano C, Di Bari M, et al. M2 muscarinic receptors inhibit cell proliferation in human glioblastoma cell lines. Life Sci. 2012; 91: 113437.
  • 29
    Calogero A, Porcellini A, Lombari V, et al. Sensitivity to cisplatin in primary cell lines derived from human glioma correlates with levels of EGR-1 expression. Cancer Cell Int. 2011; 2: 115.
  • 30
    Huang JL, McLeish MJ. High-performance liquid chromatographic determination of the alkaloids in betel nut. J Chromatogr. 1989; 475: 44750.
  • 31
    Barlow RB, Weston-Smith P. The relative potencies of some agonists at M2 muscarinic receptors in guinea pig ileum, atria and bronchi. Br J Pharmacol. 1985; 85: 43740.
  • 32
    Mosman T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods. 1983; 65: 5563.
  • 33
    Ridet A, Guillouf C, Duchaud E, et al. Deregulated apoptosis is a hallmark of Fanconi anemia syndrome. Canc Res. 1997; 57: 172230.
  • 34
    Darzynkiewicz Z, Bruno S, Del Bino G, et al. Features of apoptotic cells measured by flow cytometry. Cytometry. 1992; 13: 795808.
  • 35
    Calogero A, Lombari V, De Gregorio G, et al. Inhibition of cell growth by EGR-1 in human primary cultures from malignant glioma. Cancer Cell Int. 2004; 4: 112.
  • 36
    Bordey A, Sontheimer H, Drouslard J. Muscarinic activation of BK channels induces membrane oscillations in glioma cells and leads to inhibition of cell migration. J Membrane Biol. 2000; 176: 3140.
  • 37
    Hambardzamyan D, Squatrito M, Carbajal E, et al. Glioma formation, cancer stem cells, and AKT signaling. Stem Cell Rep. 2008; 4: 20310.
  • 38
    West KA, Brognard J, Clark AS, et al. Rapid AKT activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells. J Clin Invest. 2003; 111: 8190.
  • 39
    Holland EC, Celestino J, Dai C, et al. Combined activation of Ras and AKT in neural progenitors induces glioblastoma formation in mice. Nature Gen. 2000; 25: 557.
  • 40
    McCubrey JA, Steelman LS, Chappell WH, et al. Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance. Biochim Biophys Acta. 2007; 1773: 126384.
  • 41
    Castigli E, Arcuri C, Giovagnoli L, et al. Interleukin-1beta induces apoptosis in GL15 glioblastoma-derived human cell lines. Am J Physiol Cell Physiol. 2000; 279: 20439.
  • 42
    Castigli E, Sciaccaluga M, Schiavoni G, et al. GL15 and U251 glioblastoma-derived human cell lines are peculiarly susceptible to induction of mitotic death by very low concentrations of okadaic acid. Oncol Rep. 2006; 15: 46370.
  • 43
    Lu J, Kovach JS, Johnson F, et al. Inhibition of serine/threonine phosphatase PP2A enhances cancer chemotherapy by blocking DNA damage induced defense mechanisms. Proc Natl Acad Sci USA. 2009; 106: 11697702.
  • 44
    Cheng K, Samimi R, Xie G, et al. Acetylcholine release by human colon cancer cells mediates autocrine stimulation of cell proliferation. Am J Physiol Gastrointest Liver Physiol. 2008; 295: 5917.
  • 45
    Thiers CA, Barbosa JL, Pereira BD, et al. Autonomic dysfunction and anti-M2 and β1 receptor antibodies I Chagas disease patients. Arq Bas Cardiol. 2012; 99: 7329.
  • 46
    Shah N, Khurana S, Cheng K, et al. Muscarinic receptors and ligands in cancer. Am J Physiol Cell Physiol. 2009; 296: 22132.