Changes of lysosomes in the earliest stages of the development of atherosclerosis
Article first published online: 13 MAR 2013
© 2013 The Authors Journal of Cellular and Molecular Medicine Published by Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd
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Journal of Cellular and Molecular Medicine
Volume 17, Issue 5, pages 626–635, May 2013
How to Cite
Bobryshev, Y. V., Shchelkunova, T. A., Morozov, I. A., Rubtsov, P. M., Sobenin, I. A., Orekhov, A. N. and Smirnov, A. N. (2013), Changes of lysosomes in the earliest stages of the development of atherosclerosis. Journal of Cellular and Molecular Medicine, 17: 626–635. doi: 10.1111/jcmm.12042
- Issue published online: 27 MAY 2013
- Article first published online: 13 MAR 2013
- Manuscript Accepted: 21 JAN 2013
- Manuscript Received: 9 OCT 2012
- initial lesion;
- fatty streak;
One of hypotheses of atherosclerosis is based on a presumption that the zones prone to the development of atherosclerosis contain lysosomes which are characterized by enzyme deficiency and thus, are unable to dispose of lipoproteins. The present study was undertaken to investigate the characteristics and changes of lysosomes in the earliest stages of the development of atherosclerosis. Electron microscopic immunocytochemistry revealed that there were certain changes in the distribution of CD68 antigen in lysosomes along the ‘normal intima-initial lesion-fatty streak’ sequence. There were no significant changes found in the key mRNAs encoding for the components of endosome/lysosome compartment in initial atherosclerotic lesions, but in fatty streaks, the contents of EEA1 and Rab5a mRNAs were found to be diminished while the contents of CD68 and p62 mRNAs were increased, compared with the intact tissue. The study reinforces a view that changes occurring in lysosomes play a role in atherogenesis from the very earlier stages of the disease.