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jcmm12116-sup-0001-FigS1-S7.docxWord document3489KFigure S1. Method for culturing EPCs: Mononuclear cells (MNC) were isolated from spleen (mouse) or blood (human) by Ficoll gradient density and seeded in fibronectin (FN)-coated plates with EGM-2 medium. Figure S2. Genotype characterization of wild-type (WT) and knockout (MMP-9/KO) mice. Figure S3. Immunocytochemistry of cobblestone-type mouse OECs. Figure S4. Representative microscopy images of time-lapse imaging assay of mouse OECs on Matrigel™ matrix at different time-points. Figure S5. Gelatin zymography of conditioned media (CM) detected gelatinolytic activity of pro-MMP-9 in media from WT sham and ischaemic EPC. Figure S6. Cell viability determined by MTT assay after MMP inhibitors or vehicle treatment. Figure S7. Brain vasculature in WT and MMP-9/KO mice after cerebral ischaemia.
jcmm12116-sup-0002-VideoS1.avivideo/avi9495KVideo S1. Twenty-four hours of time-lapse imaging MatrigelTM assay of mouse WT control OECs (100×).
jcmm12116-sup-0003-VideoS2.avivideo/avi9496KVideo S2. Twenty-four hours of time-lapse imaging MatrigelTM assay of mouse WT ischaemic OECs (100×).
jcmm12116-sup-0004-VideoS3.avivideo/avi9496KVideo S3. Twenty-four hours of time-lapse imaging MatrigelTM assay of mouse MMP-9/KO control OECs (100×).
jcmm12116-sup-0005-VideoS4.avivideo/avi9496KVideo S4. Twenty-four hours of time-lapse imaging MatrigelTM assay of mouse MMP-9/KO ischaemic OECs (100×).

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