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Table S1 50% inhibiting concentration (IC50) of C2, CDDP and GA on cancer cells and normal cells.

Table S2 50% inhibiting concentration (IC50) of C2 and CDDP on CD133+ and CD133 HNSCC cells.

Fig. S1 The half-life of C2 and GA was detected by metabolic stability assay combined with LS/MS/MS assay. GA or C2 were incubated with rat liver microsomes for indicated time and the concentration was determined with LC/MS/MS. The half-life of GA and C2 was 3.1 and 6.3 hrs, respectively.

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