These authors contributed equally to this work.
A new gamboge derivative Compound 2 inhibits cancer stem-like cells via suppressing EGFR tyrosine phosphorylation in head and neck squamous cell carcinoma
Version of Record online: 23 SEP 2013
© 2013 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Journal of Cellular and Molecular Medicine
Volume 17, Issue 11, pages 1422–1433, November 2013
How to Cite
Deng, R., Wang, X., Liu, Y., Yan, M., Hanada, S., Xu, Q., Zhang, J., Han, Z., Chen, W. and Zhang, P. (2013), A new gamboge derivative Compound 2 inhibits cancer stem-like cells via suppressing EGFR tyrosine phosphorylation in head and neck squamous cell carcinoma. Journal of Cellular and Molecular Medicine, 17: 1422–1433. doi: 10.1111/jcmm.12129
- Issue online: 23 DEC 2013
- Version of Record online: 23 SEP 2013
- Manuscript Accepted: 14 AUG 2013
- Manuscript Received: 17 FEB 2013
- National Natural Science Foundation of China. Grant Numbers: 81272978, 81072171, 91229103, 81201715
- Shanghai Science and Technology Committee. Grant Numbers: 09431902200, 10XD1402500, 11DZ2291800
- China Postdoctoral Science Foundation. Grant Number: 2011M500610
- Shanghai Institutions of Higher Learning. Grant Number: 1220000243
Table S1 50% inhibiting concentration (IC50) of C2, CDDP and GA on cancer cells and normal cells.
Table S2 50% inhibiting concentration (IC50) of C2 and CDDP on CD133+ and CD133− HNSCC cells.
Fig. S1 The half-life of C2 and GA was detected by metabolic stability assay combined with LS/MS/MS assay. GA or C2 were incubated with rat liver microsomes for indicated time and the concentration was determined with LC/MS/MS. The half-life of GA and C2 was 3.1 and 6.3 hrs, respectively.
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