These authors equally contributed to this work.
Unbalanced distribution of materials: the art of giving rise to hepatocytes from liver stem/progenitor cells
Article first published online: 28 NOV 2013
© 2013 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Journal of Cellular and Molecular Medicine
Volume 18, Issue 1, pages 1–14, January 2014
How to Cite
Liu, W.-H., Ren, L.-N., Chen, T., You, N., Liu, L.-Y., Wang, T., Yan, H.-T., Luo, H. and Tang, L.-J. (2014), Unbalanced distribution of materials: the art of giving rise to hepatocytes from liver stem/progenitor cells. Journal of Cellular and Molecular Medicine, 18: 1–14. doi: 10.1111/jcmm.12183
- Issue published online: 30 DEC 2013
- Article first published online: 28 NOV 2013
- Manuscript Accepted: 8 OCT 2013
- Manuscript Received: 29 JUL 2013
- National Natural Science Foundation of China. Grant Numbers: 81302168, 81172061, 81370016, 8117041
- liver stem/progenitor cells;
- hepatic differentiation, unbalanced distribution theory;
- liver regeneration
Liver stem/progenitor cells (LSPCs) are able to duplicate themselves and differentiate into each type of cells in the liver, including mature hepatocytes and cholangiocytes. Understanding how to accurately control the hepatic differentiation of LSPCs is a challenge in many fields from preclinical to clinical treatments. This review summarizes the recent advances made to control the hepatic differentiation of LSPCs over the last few decades. The hepatic differentiation of LSPCs is a gradual process consisting of three main steps: initiation, progression and accomplishment. The unbalanced distribution of the affecting materials in each step results in the hepatic maturation of LSPCs. As the innovative and creative works for generating hepatocytes with full functions from LSPCs are gradually accumulated, LSPC therapies will soon be a new choice for treating liver diseases.