These authors contributed equally to this work.
Telocytes in liver: electron microscopic and immunofluorescent evidence
Version of Record online: 25 NOV 2013
© 2013 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Journal of Cellular and Molecular Medicine
Volume 17, Issue 12, pages 1537–1542, December 2013
How to Cite
Xiao, J., Wang, F., Liu, Z. and Yang, C. (2013), Telocytes in liver: electron microscopic and immunofluorescent evidence. Journal of Cellular and Molecular Medicine, 17: 1537–1542. doi: 10.1111/jcmm.12195
- Issue online: 25 DEC 2013
- Version of Record online: 25 NOV 2013
- Manuscript Accepted: 26 OCT 2013
- Manuscript Received: 24 AUG 2013
- National Natural Science Foundation of China. Grant Numbers: 81070343, 81370559, 81200669
- Shanghai Innovation Program. Grant Number: 12431901002
- Shanghai Municipal Education Commission. Grant Number: 13YZ014
- Foundation for University Young Teachers by Shanghai Municipal Education Commission Innovation Foundation of Shanghai University. Grant Number: sdcx2012038
- Leading Academic Discipline Project of Shanghai Municipal Education Commission “Molecular Physiology”
- Shanghai Municipal Science and Technology Committee. Grant Number: 13DZ2272100
- PDGFR-α, β;
- hepatic putative stem cells
Hepatic interstitial cells play a vital role in regulating essential biological processes of the liver. Telocytes (TCs), a novel type of interstitial cells firstly identified by Popescu and his coworkers, have been reported in many tissues and organs, but not yet in liver (go to http://www.telocytes.com). We used transmission electron microscopy and immunofluorescence (double labelling for CD34 and c-kit/CD117, or vimentin, or PDGF Receptor-α, or β) to provide evidence for the existence of TCs in mice liver. The distribution of TCs in liver was found to be of similar density in the four hepatic lobes. In conclusion, here we show the presence of TCs in mice liver. It remains to be determined the possible roles of TCs in the control of liver homeostasis and regeneration, the more so as a close special relationship was found between TCs and hepatic putative stem (progenitor) cells.