These authors contribute equally to this work.
Candidate tumour suppressor CCDC19 regulates miR-184 direct targeting of C-Myc thereby suppressing cell growth in non-small cell lung cancers
Article first published online: 26 JUN 2014
© 2014 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Journal of Cellular and Molecular Medicine
Volume 18, Issue 8, pages 1667–1679, August 2014
How to Cite
Liu, Z., Mai, C., Yang, H., Zhen, Y., Yu, X., Hua, S., Wu, Q., Jiang, Q., Zhang, Y., Song, X. and Fang, W. (2014), Candidate tumour suppressor CCDC19 regulates miR-184 direct targeting of C-Myc thereby suppressing cell growth in non-small cell lung cancers. Journal of Cellular and Molecular Medicine, 18: 1667–1679. doi: 10.1111/jcmm.12317
- Issue published online: 2 SEP 2014
- Article first published online: 26 JUN 2014
- Manuscript Accepted: 3 APR 2014
- Manuscript Received: 16 OCT 2013
- National Nature Science Fund of China. Grant Numbers: 81101781, 81071632
- Guangdong Province Breeding Project Plan. Grant Number: LYM11102
|jcmm12317-sup-0001-FigS1.tif||image/tif||538K||Figure S1 C-Myc was predicted to be a potential target of miR-184 by RNAhybrid software.|
|jcmm12317-sup-0002-FigS2.tif||image/tif||1895K||Figure S2 C-Jun binding sites and its mutant sites in miR-184 promoter. MT1: The mutation of site 1; MT2: The mutation of site 2; MT1+2: The combined mutations of MT1 and MT2.|
|jcmm12317-sup-0003-FigS3.tif||image/tif||358K||Figure S3 The expression of miR-184 was suppressed by its specific inhibitor in A549 and SPCA1 cells.|
|jcmm12317-sup-0004-FigS4.tif||image/tif||268K||Figure S4 miR-184 did not regulate the expression of CCDC19 in NSCLC.|
|jcmm12317-sup-0005-FigS5.tif||image/tif||260K||Figure S5 Ideograph of tumour suppressor CCDC19 in modulating cell proliferation.|
|jcmm12317-sup-0006-TableS1.doc||Word document||27K||Table S1 siRNAs for CCDC19.|
|jcmm12317-sup-0007-TableS2.doc||Word document||28K||Table S2 Sequences of miR-184 mimics and negative control, miR-184 inhibitor and inhibitor negative control.|
|jcmm12317-sup-0008-TableS3.doc||Word document||26K||Table S3 Sequences of miR-184 and U6.|
|jcmm12317-sup-0009-TableS4.doc||Word document||25K||Table S4 Primer sequences for C-MYC CDS.|
|jcmm12317-sup-0010-TableS5.doc||Word document||27K||Table S5 ChIP Primer sequences for miR-184 promoter.|
|jcmm12317-sup-0011-TableS6.doc||Word document||26K||Table S6 Down-regulation of NESG1 protein in NPC compared to NP epithelium tissues.|
|jcmm12317-sup-0012-TableS7.doc||Word document||55K||Table S7 Correlation between the clinicopathological characteristics and expression of NESG1 protein in lung cancer.|
|jcmm12317-sup-0013-TableS8.doc||Word document||56K||Table S8 Summary of univariate and multivariate Cox regression analysis of overall survival duration.|
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