Conflict of interest and source of funding statement
Randomized Clinical Trial
Implant decontamination during surgical peri-implantitis treatment: a randomized, double-blind, placebo-controlled trial
Article first published online: 4 DEC 2012
© 2012 John Wiley & Sons A/S
Journal of Clinical Periodontology
Volume 40, Issue 2, pages 186–195, February 2013
How to Cite
Implant decontamination during surgical peri-implantitis treatment: a randomized, double-blind, placebo-controlled trial. J Clin Periodontol 2013; 40: 186–195. doi: 10.1111/jcpe.12034, , , , ,
The authors declare that they have no conflict of interest. The test- and placebo-solutions were provided for free by Dentaid SL (Cerdanyola, Spain).
- Issue published online: 11 JAN 2013
- Article first published online: 4 DEC 2012
- Accepted manuscript online: 26 OCT 2012 09:30AM EST
- Manuscript Accepted: 1 OCT 2012
Vol. 41, Issue 1, 94, Article first published online: 12 DEC 2013
- cetylpyridinium chloride;
- resective surgery
The objective of this randomized, double-blind, placebo-controlled trial was to study the effect of implant surface decontamination with chlorhexidine (CHX)/cetylpyridinium chloride (CPC) on microbiological and clinical parameters.
Material & Methods
Thirty patients (79 implants) with peri-implantitis were treated with resective surgical treatment consisting of apically re-positioned flap, bone re-contouring and surface debridement and decontamination. Patients were randomly allocated to decontamination with 0.12% CHX + 0.05% CPC (test-group) or a placebo-solution (without CHX/CPC, placebo-group). Microbiological parameters were recorded during surgery; clinical and radiographical parameters were recorded before (pre-) treatment (baseline), and at 3, 6 and 12 months after treatment.
Nine implants in two patients in the placebo-group were lost due to severe persisting peri-implantitis. Both decontamination procedures resulted in significant reductions of bacterial load on the implant surface, but the test-group showed a significantly greater reduction than the placebo-group (log 4.21 ± 1.89 versus log 2.77 ± 2.12, p = 0.006). Multilevel analysis showed no differences between both groups in the effect of the intervention on bleeding, suppuration, probing pocket depth and radiographical bone loss over time.
Implant surface decontamination with 0.12% CHX + 0.05% CPC in resective surgical treatment of peri-implantitis leads to a greater immediate suppression of anaerobic bacteria on the implant surface than a placebo-solution, but does not lead to superior clinical results. The long-term microbiological effect remains unknown.