Implant decontamination during surgical peri-implantitis treatment: a randomized, double-blind, placebo-controlled trial

Authors

  • Yvonne C. M. de Waal,

    Corresponding author
    • Center for Dentistry and Oral Hygiene, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
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  • Gerry M. Raghoebar,

    1. Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
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  • James J. R. Huddleston Slater,

    1. Center for Dentistry and Oral Hygiene, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    2. Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
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  • Henny J. A. Meijer,

    1. Center for Dentistry and Oral Hygiene, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    2. Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
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  • Edwin G. Winkel,

    1. Center for Dentistry and Oral Hygiene, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
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  • Arie Jan van Winkelhoff

    1. Center for Dentistry and Oral Hygiene, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    2. Department of Medical and Oral Microbiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
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Errata

This article is corrected by:

  1. Errata: Corrigendum Volume 41, Issue 1, 94, Article first published online: 12 December 2013

  • Conflict of interest and source of funding statement

    The authors declare that they have no conflict of interest. The test- and placebo-solutions were provided for free by Dentaid SL (Cerdanyola, Spain).

Address:

Yvonne de Waal

Center for Dentistry and Oral Hygiene

University Medical Center Groningen

Antonius Deusinglaan 1

9713 AV Groningen

The Netherlands

E-mail: y.c.m.de.waal@umcg.nl

Abstract

Aim

The objective of this randomized, double-blind, placebo-controlled trial was to study the effect of implant surface decontamination with chlorhexidine (CHX)/cetylpyridinium chloride (CPC) on microbiological and clinical parameters.

Material & Methods

Thirty patients (79 implants) with peri-implantitis were treated with resective surgical treatment consisting of apically re-positioned flap, bone re-contouring and surface debridement and decontamination. Patients were randomly allocated to decontamination with 0.12% CHX + 0.05% CPC (test-group) or a placebo-solution (without CHX/CPC, placebo-group). Microbiological parameters were recorded during surgery; clinical and radiographical parameters were recorded before (pre-) treatment (baseline), and at 3, 6 and 12 months after treatment.

Results

Nine implants in two patients in the placebo-group were lost due to severe persisting peri-implantitis. Both decontamination procedures resulted in significant reductions of bacterial load on the implant surface, but the test-group showed a significantly greater reduction than the placebo-group (log 4.21 ± 1.89 versus log 2.77 ± 2.12, = 0.006). Multilevel analysis showed no differences between both groups in the effect of the intervention on bleeding, suppuration, probing pocket depth and radiographical bone loss over time.

Conclusion

Implant surface decontamination with 0.12% CHX + 0.05% CPC in resective surgical treatment of peri-implantitis leads to a greater immediate suppression of anaerobic bacteria on the implant surface than a placebo-solution, but does not lead to superior clinical results. The long-term microbiological effect remains unknown.

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