Non-surgical periodontal therapy decreases serum elastase levels in aggressive but not in chronic periodontitis

Authors

  • Peter Eickholz,

    Corresponding author
    • Department of Periodontology, Centre for Dental, Oral, and Maxillofacial Medicine (Carolinum), Johann Wolfgang Goethe-University Frankfurt/Main, Frankfurt, Germany
    Search for more papers by this author
  • Yasemin Siegelin,

    1. Department of Periodontology, Centre for Dental, Oral, and Maxillofacial Medicine (Carolinum), Johann Wolfgang Goethe-University Frankfurt/Main, Frankfurt, Germany
    Search for more papers by this author
  • Susanne Scharf,

    1. Department of Periodontology, Centre for Dental, Oral, and Maxillofacial Medicine (Carolinum), Johann Wolfgang Goethe-University Frankfurt/Main, Frankfurt, Germany
    Search for more papers by this author
  • Beate Schacher,

    1. Department of Periodontology, Centre for Dental, Oral, and Maxillofacial Medicine (Carolinum), Johann Wolfgang Goethe-University Frankfurt/Main, Frankfurt, Germany
    Search for more papers by this author
  • Gerhard M. Oremek,

    1. Department of Laboratory Medicine, Centre for Internal Medicine, Hospital of the Johann Wolfgang Goethe-University Frankfurt/Main, Frankfurt, Germany
    Search for more papers by this author
  • Hildegund Sauer-Eppel,

    1. Department of Laboratory Medicine, Centre for Internal Medicine, Hospital of the Johann Wolfgang Goethe-University Frankfurt/Main, Frankfurt, Germany
    Search for more papers by this author
  • Ralf Schubert,

    1. Pneumology, Allergology and Cystic Fibrosis, Children's Hospital, Hospital of the Johann Wolfgang Goethe-University Frankfurt/Main, Frankfurt, Germany
    Search for more papers by this author
  • Martin Wohlfeil

    1. Department of Periodontology, Centre for Dental, Oral, and Maxillofacial Medicine (Carolinum), Johann Wolfgang Goethe-University Frankfurt/Main, Frankfurt, Germany
    Search for more papers by this author

  • Conflict of interest and source of funding statement

    The authors declare that they have no conflicts of interest. This study was in part self-funded by the authors and their institutions and in part funded by grants of the German Society of Periodontology (DGP), the German Society of Dental, Oral, and Maxillofacial Medicine (DGZMK), and the New Working Group for Periodontology (NAgP).

Address:

Peter Eickholz

Poliklinik für Parodontologie, ZZMK (Carolinum), Johann Wolfgang Goethe-Universität Frankfurt, Theodor-Stern-Kai 7 (Haus 29), 60596 Frankfurt am Main, Germany

E-mail: eickholz@med.uni-frankfurt.de

Abstract

Aim

Assessment of the effect of non-surgical periodontal therapy (SRP) on serum inflammatory parameters in patients with untreated aggressive (AgP) and chronic (ChP) periodontitis.

Methods

Overall, 31 ChP and 29 AgP were examined clinically prior to and 12 weeks after SRP (subgingival scaling of all pockets within 2 days) with systemic antibiotics for patients positive for Aggregatibacter actinomycetemcomitans (14 AgP, 9 ChP). Blood was sampled prior to, one day, 6, and 12 weeks after the first SRP visit. Serum elastase, C-reactive protein (CRP), lipopolysaccharide-binding protein (LBP), interleukin (IL) 6, 8, and leukocyte counts were assessed.

Results

At baseline, serum elastase, CRP, and LBP were significantly (< 0.01) higher in AgP than ChP. Serum elastase, CRP, LBP, and IL-6 were significantly (< 0.001) elevated one day after scaling in both groups. Both groups showed significant clinical improvement (< 0.001). A significant difference was observed regarding change of serum elastase 12 weeks after SRP between AgP and ChP (= 0.015). Multiple regression analysis revealed AgP, African origin, and bleeding on probing to be associated with more pronounced elastase reduction. CRP reduction was associated with African origin, systemic antibiotics, and baseline probing pocket depth.

Conclusion

SRP results in serum elastase reduction in AgP but not in ChP.

Ancillary