Infection and inflammatory mechanisms


  • Conflict of interest and sources of funding statement

    The authors declare no conflict of interest. The workshop was funded by an unrestricted educational grant from Colgate-Palmolive to the European Federation of Periodontology and the American Academy of Periodontology.

  • The proceedings of the workshop were jointly and simultaneously published in the Journal of Clinical Periodontology and Journal of Periodontology.


Thomas E. Van Dyke

Vice President for Clinical and Translational Research

Chair, Department of Applied Oral Sciences

Senior Member of the Staff

The Forsyth Institute

245 First Street

Cambridge, MA 02142 USA



This introductory article examines the potential mechanisms that may play a role in the associations between periodontitis and the systemic conditions being considered in the EFP/AAP Workshop in Segovia, Spain. Three basic mechanisms have been postulated to play a role in these interactions; metastatic infections, inflammation and inflammatory injury, and adaptive immunity. The potential role of each alone and together is considered in in vitro and animal studies and in human studies when available. This is not a systematic or critical review, but rather an overview of the field to set the stage for the critical reviews in each of the working groups.