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Nitric oxide production, systemic inflammation and lipid metabolism in periodontitis patients: possible gender aspect

Authors

  • Oleh Andrukhov,

    1. Central Research Unit, Bernhard Gottlieb School of Dentistry, Medical University of Vienna, Vienna, Austria
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  • Hady Haririan,

    1. Division of Conservative Dentistry, Periodontology and Prophylaxis, Bernhard Gottlieb School of Dentistry, Medical University of Vienna, Vienna, Austria
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  • Kristina Bertl,

    1. Division of Oral Surgery, Bernhard Gottlieb School of Dentistry, Medical University of Vienna, Vienna, Austria
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  • Wolf-Dieter Rausch,

    1. Department of Biomedical Sciences, Institute for Chemistry and Biochemistry, University of Veterinary Medicine, Vienna, Austria
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  • Hans-Peter Bantleon,

    1. Division of Orthodontics, Bernhard Gottlieb School of Dentistry, Medical University of Vienna, Vienna, Austria
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  • Andreas Moritz,

    1. Division of Conservative Dentistry, Periodontology and Prophylaxis, Bernhard Gottlieb School of Dentistry, Medical University of Vienna, Vienna, Austria
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  • Xiaohui Rausch-Fan

    Corresponding author
    1. Central Research Unit, Bernhard Gottlieb School of Dentistry, Medical University of Vienna, Vienna, Austria
    2. Division of Orthodontics, Bernhard Gottlieb School of Dentistry, Medical University of Vienna, Vienna, Austria
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  • Conflict of interest and source of funding statement

    Greiner Bio-One supported this study by financing materials (reagents and saliva collection system; Medical University of Vienna, §26, project number AP00345OFF). The authors declare that they have no conflict of interests.

Abstract

Aim

Nitric oxide (NO) plays a crucial role in vascular tone regulation and is involved in pathogenesis of periodontitis. In this cross-sectional study, we investigated the serum and saliva levels of NO metabolites in periodontal disease and their relationship with serum C-reactive protein (CRP) levels, lipids metabolism and periodontal disease severity.

Material and Methods

Serum and saliva were collected from non-smoking patients with generalized severe periodontitis (n = 89) and healthy controls (n = 56). Serum and salivary levels of NO metabolites, serum levels of high density lipoproteins (HDL), low density lipoproteins (LDL), triglycerides, cholesterol and CRP were measured. Data were analysed in whole population and in different gender groups.

Results

Periodontitis patients exhibited significantly lower serum and saliva levels of NO metabolites and significantly higher LDL, cholesterol and CRP levels than control group. Similar findings were observed within male but not within female population. Serum NO metabolites levels exhibited significant negative correlation with CRP in whole population and in male population. Significant positive correlation of serum NO metabolite levels with HDL levels was observed in whole population.

Conclusion

NO production is reduced in periodontitis, especially in male population. Gender might be an important factor in assessing risk of cardiovascular disease in periodontitis.

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