These authors contributed equally to this work.
Bisphenol A in relation to behavior and learning of school-age children
Article first published online: 28 FEB 2013
© 2013 The Authors. Journal of Child Psychology and Psychiatry © 2013 Association for Child and Adolescent Mental Health.
Journal of Child Psychology and Psychiatry
Volume 54, Issue 8, pages 890–899, August 2013
How to Cite
Hong, S.-B., Hong, Y.-C., Kim, J.-W., Park, E.-J., Shin, M.-S., Kim, B.-N., Yoo, H.-J., Cho, I.-H., Bhang, S.-Y. and Cho, S.-C. (2013), Bisphenol A in relation to behavior and learning of school-age children. Journal of Child Psychology and Psychiatry, 54: 890–899. doi: 10.1111/jcpp.12050
Conflict of interest statement: The authors have declared that they have no conflicts of interest.
- Issue published online: 18 JUL 2013
- Article first published online: 28 FEB 2013
- Manuscript Accepted: 13 DEC 2012
- Bisphenol A;
- child behavior;
- child learning;
- nonmonotonic dose–response
Bisphenol A (BPA) has been shown to affect brain and behavior in rodents and nonhuman primates, but there are few studies focusing on its relationship to human neurobehavior. We aimed to investigate the relationship between environmental exposure to BPA and childhood neurobehavior.
Urinary BPA concentrations and behavioral and learning characteristics were assessed in a general population of 1,089 children, aged 8–11 years. The main outcome measures were the Child Behavior Checklist (CBCL) and the Learning Disability Evaluation Scale (LDES).
Urinary levels of BPA were positively associated with the CBCL total problems score and negatively associated with the learning quotient from the LDES. The linear association with the CBCL anxiety/depression score and the quadratic association with the LDES listening score were significant after correction for multiple comparisons.
Environmental exposure to BPA might be associated with childhood behavioral and learning development. The results suggest possible nonmonotonic relationships.