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Polymorphisms of the HTR3B gene are associated with post-surgery emesis in a Chinese Han population

Authors

  • Xiao-Xu Ma MD,

    1. Department of Anesthesiology, Sir Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine, Hangzhou, China
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  • Qi-Xing Chen MD,

    1. Department of Anesthesiology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
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  • Shui-Jing Wu MD,

    1. Department of Anesthesiology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
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  • Yan Hu MD,

    1. Department of Anesthesiology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
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  • Xiang-Ming Fang PhD

    Corresponding author
    1. Department of Anesthesiology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
    • Department of Anesthesiology, Sir Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine, Hangzhou, China
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Correspondence: Dr Xiang-Ming Fang, 79 Qing-Chun Road, Hangzhou, Zhejiang 310003, China. Tel.: 086 571 86091799; fax: 0571-86091799; e-mail: xiangming_fang@163.com

Summary

What is known and Objectives

The serotoninergic receptor 5-hydroxytryptamine (serotonin) receptor 3 (HTR3) is instrumental in the regulation of nausea and emesis (vomiting).This study investigated whether common genomic variations of the A and B subunits of HTR3 (HTR3A, HTR3B) are associated with the incidence of post-operative vomiting in a Chinese Han population.

Methods

Two hundred and thirty-one female Chinese Han patients undergoing gynaecological surgery with standardized general anaesthesia were recruited for the study. Clinical symptoms after surgery were recorded and direct DNA sequencing was performed to detect polymorphisms of HTR3A and HTR3B.

Results

Five single nucleotide polymorphisms (SNPs) in HTR3A and HTR3B were found, with R2 > 0·8 and minor allele frequency > 10%. One of these (rs3758987 in HTR3B) was statistically associated with vomiting, after adjusting for body weight, body mass index and duration of general anaesthesia in dominant and additive models (= 0·047 and = 0·034).

What is new and Conclusion

The HTR3B rs3758987 SNP might serve as a predictor of post-operative vomiting in Chinese Han patients undergoing gynaecological laparoscopic surgery.

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