Ischemic heart disease is associated with vertebral fractures in patients with type 2 diabetes mellitus
Version of Record online: 1 MAR 2013
© 2013 Asian Association for the Study of Diabetes and Wiley Publishing Asia Pty Ltd
Journal of Diabetes Investigation
Volume 4, Issue 3, pages 310–315, May 2013
How to Cite
(J Diabetes Invest, doi: 10.1111/jdi.12034, 2013)
- Issue online: 6 MAY 2013
- Version of Record online: 1 MAR 2013
- Manuscript Accepted: 11 NOV 2012
- Manuscript Revised: 4 NOV 2012
- Manuscript Received: 4 SEP 2012
- Fondo de Investigación Sanitaria. Grant Number: PI052114
- RETICEF. Grant Number: RD06/0013/1014
- Ischemic heart disease;
- Type 2 diabetes mellitus;
- Vertebral fractures
Discordant results about the relationship between diabetes complications and the risk of fragility fractures have been reported. Our aims were to analyze the factors related to morphometric vertebral fractures (VFs) in patients with type 2 diabetes mellitus, and to explore the association between the presence of VFs and the main cardiovascular risk factors.
Materials and Methods
We carried out a cross-sectional study including 123 patients with type 2 diabetes mellitus, and in 72 of these patients we recorded data about the risk factors for VFs and comorbidities of diabetes including diabetes-related microvascular disease and cardiovascular disease.
In the crude analysis, diabetic retinopathy (odds ratio [OR] 4.09, 95% confidence interval [CI] 1.01–12.5), ischemic heart disease (OR 5.02, 95% CI 1.1–9.7) and waist circumference (OR 1.06, 95% CI 1.006–1.114) were related to VFs. In the full model (adjusted for age, sex, body mass index), ischemic heart disease was the only determinant of VF (OR 3.33, CI 1.02–10.91, P = 0.047); whereas diabetic retinopathy did not reached significance (OR 2.27, CI 0.71–7.27, P = 0.16).
In summary, ischemic heart disease is associated with an increased risk of VFs in type 2 diabetes mellitus.