• Open Access

Effect of periodontal treatment on glycemic control of patients with diabetes: A systematic review and meta-analysis

Authors

  • Stefano Corbella,

    Corresponding author
    • Department of Biomedical, Surgical and Dental Sciences, Oral Implantology Research Center, Università degli Studi di Milano, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy
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  • Luca Francetti,

    1. Department of Biomedical, Surgical and Dental Sciences, Oral Implantology Research Center, Università degli Studi di Milano, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy
    2. Department of Biomedical, Surgical and Dental Sciences, Oral Health Research Center, Università degli Studi di Milano, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy
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  • Silvio Taschieri,

    1. Department of Biomedical, Surgical and Dental Sciences, Oral Health Research Center, Università degli Studi di Milano, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy
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  • Francesca De Siena,

    1. Department of Biomedical, Surgical and Dental Sciences, Oral Health Research Center, Università degli Studi di Milano, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy
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  • Massimo Del Fabbro

    1. Department of Biomedical, Surgical and Dental Sciences, Oral Implantology Research Center, Università degli Studi di Milano, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy
    2. Department of Biomedical, Surgical and Dental Sciences, Oral Health Research Center, Università degli Studi di Milano, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy
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Corresponding author. Stefano Corbella Tel.: +39-02-50319950 Fax: +39-02-50319960

E-mail address: stefano.corbella@gmail.com

Abstract

Aims/Introduction

The aim of the present study was to investigate whether non-surgical periodontal treatment reduces glycated hemoglobin (HbA1c) and fasting plasma glucose (FPG) levels in diabetic patients.

Materials and Methods

An electronic search was carried out on MEDLINE (through PubMed interface), EMBASE and the Cochrane Central Register of Controlled Trials. Randomized controlled trials with a minimum of 3 months follow up were included. The risk of bias was assessed for each study. A meta-analysis was carried out to evaluate the effect of non-surgical periodontal treatment on HbA1c and FPG levels. The effect of the adjunctive use of antimicrobials was also assessed.

Results

A total of 15 studies were included. A reduction of −0.38% (95% confidence interval [CI] −0.23 to −0.53) after 3–4 months (P < 0.001) and of −0.31% (95% CI 0.11 to −0.74) after 6 months (P = 0.15) of follow-up was found for HbA1c, favoring the treatment group. Similarly, in treated patients, a significantly greater decrease in FPG was observed in respect to control participants. Such difference amounted to −9.01 mg/dL (95% CI −2.24 to −15.78) after 3–4 months (P = 0.009) and −13.62 mg/dL (95% CI 0.45 to −27.69) after 6 months (P = 0.06) from treatment, respectively. In participants treated with adjunctive antimicrobials, a non-significant increase of HbA1c was observed 3 months after treatment, whereas FPG decreased by 0.27 mg/dL (95% CI 39.56 to −40.11; P = 0.99).

Conclusions

The meta-analysis showed that non-surgical periodontal treatment improves metabolic control in patients with both periodontitis and diabetes.

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