Conflict of interest The authors declare no conflict of interests.
1468-3083/asset/JDV_left.gif?v=1&s=1f5077e9ad670d0243350067014f92a67f0587c2)
SHORT REPORT
You have free access to this content
DNA methylation of the filaggrin gene adds to the risk of eczema associated with loss-of-function variants
Article first published online: 25 SEP 2012
DOI: 10.1111/jdv.12000
© 2012 The Authors. Journal of the European Academy of Dermatology and Venereology © 2012 European Academy of Dermatology and Venereology
Issue
Journal of the European Academy of Dermatology and Venereology
Volume 27, Issue 3, pages e420–e423, March 2013
Additional Information
How to Cite
Ziyab, A.H., Karmaus, W., Holloway, J.W., Zhang, H., Ewart, S. and Arshad, S.H. (2013), DNA methylation of the filaggrin gene adds to the risk of eczema associated with loss-of-function variants. Journal of the European Academy of Dermatology and Venereology, 27: e420–e423. doi: 10.1111/jdv.12000
Funding sources The epigenetic investigation was supported by National Institutes of Health, USA (R01-AI091905). The 18-year assessment of the 1989 Isle of Wight birth cohort was funded by grants from the National Institutes of Health, USA (R01 HL082925) and National Eczema Society/British Dermatological Nursing Group Research Awards.
Publication History
- Issue published online: 18 FEB 2013
- Article first published online: 25 SEP 2012
- Received: 12 May 2012; Accepted: 27 August 2012
References
- 1, , et al. Eczema. Mt Sinai J Med 2011; 78: 730–739.
- 2
- 3. Atopic dermatitis. N Engl J Med 2008; 358: 1483–1494.
- 4, , . Genetics of atopic dermatitis. J Dtsch Dermatol Ges 2011; 9: 670–676.
- 5, , . The use of the twin model to investigate the genetics and epigenetics of skin diseases with genomic, transcriptomic and methylation data. J Eur Acad Dermatol Venereol 2012; 26: 1067–1073.
- 6, , . Epigenetic mechanisms in the context of complex diseases. Cell Mol Life Sci 2007; 64: 1531–1538.
- 7, , et al. Variation, patterns, and temporal stability of DNA methylation: considerations for epigenetic epidemiology. FASEB J 2010; 24: 3135–3144.
- 8, . Commentary: the seven plagues of epigenetic epidemiology. Int J Epidemiol 2012; 41: 74–78.
- 9, , . The mammalian epigenome. Cell 2007; 128: 669–681.
- 10, , et al. Polymorphisms in the interleukin 13 and GATA binding protein 3 genes and the development of eczema during childhood. Br J Dermatol 2008; 158: 1315–1322.
- 11, . Diagnostic features of atopic dermatitis. Acta Derm Venereol Suppl (Stockh) 1980; 92: 44–47.
- 12, , et al. Interplay of filaggrin loss-of-function variants, allergic sensitization, and eczema in a longitudinal study covering infancy to 18 years of age. PLoS ONE 2012; 7: e32721.
- 13, , . A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988; 16: 1215.
- 14
- 15, , et al. A statistical framework for Illumina DNA methylation arrays. Bioinformatics 2010; 26: 2849–2855.
- 16, . More powerful procedures for multiple significance testing. Stat Med 1990; 9: 811–818.
- 17, . Intragenic DNA methylation: implications of this epigenetic mechanism for cancer research. Br J Cancer 2012; 106: 248–253.
- 18, , et al. High density DNA methylation array with single CpG site resolution. Genomics 2011; 98: 288–295.
- 19, , et al. DNA methylation in white blood cells: association with risk factors in epidemiologic studies. Epigenetics 2011; 6: 828–837.