Funding Sources None.
The effect of CD34+ cell-containing autologous platelet-rich plasma injection on pattern hair loss: a preliminary study
Article first published online: 20 DEC 2012
© 2012 The Authors. Journal of the European Academy of Dermatology and Venereology © 2012 European Academy of Dermatology and Venereology
Journal of the European Academy of Dermatology and Venereology
Volume 28, Issue 1, pages 72–79, January 2014
How to Cite
Kang, J.-S., Zheng, Z., Choi, M.J., Lee, S.-H., Kim, D.-Y. and Cho, S.B. (2014), The effect of CD34+ cell-containing autologous platelet-rich plasma injection on pattern hair loss: a preliminary study. Journal of the European Academy of Dermatology and Venereology, 28: 72–79. doi: 10.1111/jdv.12062
Conflicts of interest The authors have declared no conflicts of interest.
- Issue published online: 17 DEC 2013
- Article first published online: 20 DEC 2012
- Received: 24 August 2012; Accepted: 08 November 2012
Background Mobilized CD34+ cells in peripheral blood have angiogenic potential, which is an important factor in active hair growth. In addition, activated autologous platelet-rich plasma (PRP) has been reported to induce the proliferation of dermal papilla cells.
Objectives To investigate the clinical efficacy of interfollicular injection of CD34+ cell-containing PRP preparation for pattern hair loss.
Patients and methods CD34+ cell-containing PRP preparation was injected on the scalps of 13 patients with pattern hair loss, and 13 patients were treated with interfollicular placental extract injection as a control. The numbers of platelets in PRP were microscopically counted and CD34+ cells were evaluated with flow cytometry.
Results Three months after the first treatment, the patients presented clinical improvement in the mean number of hairs, 20.5 ± 17.0% (P < 0.0001), mean hair thickness, 31.3 ± 30.1% (P < 0.0001), and mean two-point score, 84.4 ± 51.7% (P < 0.0001) compared with baseline values. At 6 months, the patients presented clinical improvement in mean hair count, 29.2 ± 17.8% (P < 0.0001), mean hair thickness, 46.4 ± 37.5% (P < 0.0001), and mean two-point score, 121.3 ± 66.8% (P < 0.0001) compared with baseline. The MIXED procedure revealed that CD34+ cell-containing PRP treatment presented a higher degree of improvement than placental extract treatment in hair thickness (P = 0.027) and overall clinical improvement (P = 0.023).
Conclusion Our data suggest that the interfollicular injection of autologous CD34+ cell-containing PRP preparation has a positive therapeutic effect on male and female pattern hair loss without remarkable major side-effects.