Shiu-Dong Chung and Kuo-Hsien Wang have equal contribution to this manuscript.
Scabies increased the risk of chronic kidney disease: a 5-year follow-up study
Article first published online: 1 FEB 2013
© 2013 The Authors Journal of the European Academy of Dermatology and Venereology © 2013 European Academy of Dermatology and Venereology
Journal of the European Academy of Dermatology and Venereology
Volume 28, Issue 3, pages 286–292, March 2014
How to Cite
Chung, S.-D., Wang, K.-H., Huang, C.-C. and Lin, H.-C. (2014), Scabies increased the risk of chronic kidney disease: a 5-year follow-up study. Journal of the European Academy of Dermatology and Venereology, 28: 286–292. doi: 10.1111/jdv.12099
Conflict of interest
- Issue published online: 19 FEB 2014
- Article first published online: 1 FEB 2013
- Manuscript Accepted: 19 DEC 2012
- Manuscript Received: 20 OCT 2012
The most documented complication of scabies has been reported to be infection by group A streptococci, which has in turn been suggested to contribute to the development of glomerulonephritis.
This study aimed to investigate the risk of chronic kidney disease (CKD) subsequent to scabies utilizing a population-based dataset in Taiwan.
This retrospective matched-cohort study included 5071 subjects with scabies and 25 355 randomly selected comparison subjects. We individually tracked each subject for a 5-year period to identify those who subsequently received a diagnosis of CKD during the follow-up period. Stratified Cox proportional hazards regressions were performed to compute the hazard ratio (HR) of CKD during the 5-year follow-up period.
The incidence rate of CKD during the 5-year follow-up period was 9.66 (8.51–10.93) per 1,000 person-years and 6.24 (5.82–6.69) per 1000 person-years for subjects with and without scabies respectively. The HR for CKD during the 5-year follow-up period for subjects with scabies was 1.34 (95% CI = 1.15–1.56) that of comparison subjects after adjusting for monthly income, hypertension, diabetes, obesity, stroke, coronary heart disease, chronic obstructive pulmonary disease, tobacco use disorder, hyperlipidemia and alcohol abuse during the 5-year follow-up period. Male subjects with scabies were 1.40 (95% CI = 1.14–1.71) times more likely than comparison subjects to suffer from subsequent CKD, and female study subjects were 1.27 (95% CI = 1.05–1.61) times more likely.
We concluded that there was an increased risk for CKD among patients suffering from scabies.