New developments in our understanding of psoriatic arthritis and their impact on the diagnosis and clinical management of the disease
Article first published online: 1 AUG 2013
© 2013 European Academy of Dermatology and Venereology
Journal of the European Academy of Dermatology and Venereology
How to Cite
Boehncke, W.H., Kirby, B., FitzGerald, O. and van de Kerkhof, P.C.M. (2013), New developments in our understanding of psoriatic arthritis and their impact on the diagnosis and clinical management of the disease. Journal of the European Academy of Dermatology and Venereology. doi: 10.1111/jdv.12222
Conflicts of interest
- Conflicts of interest
- Professor Brian Kirby is in receipt of unrestricted grants from Pfizer, Janssen and Abbott Ltd. He acts as a consultant for Pfizer, Janssen and Abbott Ltd. Professor Oliver FitzGerald has received honoraria and grant support from Pfizer, Abbott, MSD, UCB, Roche and BMS. Professor Dr P.C.M. van de Kerkhof has consultancy services for Celgene, Centocor, Allmirall, Amgen, Pfizer, Abbott, Actelion, Galderma, Novartis, Jansen Cilag and Leo Pharma. He carries out clinical trials for Centocor, Schering Plough, Merck Serono, Abbott and Philips Lighting. Professor Dr. Wolf Henning Boehncke has consultancy services for Abbvie, Biogen Idec, MSD, Novartis, Janssen. He has been on the speakers' bureau of the following companies: AbbVie, Biogen Idec, Janssen Cilag, MSD and Pfizer, and received research grants from Wyeth (now Pfizer) and Janssen Cilag.
- Funding sources
- Manuscript developed by an unrestricted grant from Pfizer Inc.
- [Correction added on 1 November 2013, after first online publication: Pfizer Inc. was added as a funding source.]
- Article first published online: 1 AUG 2013
- Manuscript Accepted: 2 JUL 2013
- Manuscript Revised: 8 MAY 2013
- Manuscript Received: 1 FEB 2013
Psoriatic arthritis (PsA) is a spondyloarthritis with a comorbid association with psoriasis. Without appropriate treatment it can be progressive, severe, deforming and destructive. It has long been recognized that subsets of PsA patients exist, characterized by different patterns of joint involvement. Associations between development of PsA and certain human leukocyte antigens (HLA) have been established. Evidence now suggests that progression of PsA is also genetically determined. The presence of one allele (HLA-B*27) has been associated with a distinct phenotype characterized by early joint involvement, whereas development of musculoskeletal symptoms is much slower in patients with another allele, C*06. Dermatologists need to consider what these differences in genotypes and phenotypes mean for clinical practice. Delay in the diagnosis of PsA is a significant contributor to poor patient outcomes, but there is evidence that PsA is underdiagnosed among psoriasis patients attending dermatology clinics. Dermatologists need to identify PsA symptoms among their psoriasis patients and refer for rheumatological assessment where appropriate. Treatment should address all aspects of the disease, including skin, nail and joint symptoms as well as physical functioning and quality of life. The existence of distinct phenotypic and genetic PsA subsets means dermatologists need to consider which drugs are likely to be most efficacious in which patient populations. Stratification of PsA according to susceptibility genes may in future help identify patients requiring more aggressive treatment to prevent progression. Biologic therapies show efficacy in PsA, but the patient populations of clinical trials are not always representative of patients treated with biologics in clinical practice.