SEARCH

SEARCH BY CITATION

Abstract

Background

The association between psoriasis and human leucocyte antigen A (HLA-A) does not reach a consensus.

Objectives

To clarify the association between psoriasis and HLA-A.

Methods

Predefined selection criteria were applied to all relevant case–control studies (from 1972 to 2013) in two English databases.

Results

Twenty-three eligible articles covering 12 227 participants were included, in which 28 alleles were reported associated with psoriasis. Our meta-analysis results showed that nine alleles were susceptible, 12 were protective and seven were unassociated. Subgroup analyses were conducted in terms of race, clinical type and onset age. For unspecific psoriasis, only one strongly susceptible allele was found in Caucasian and three were in Asian; three strongly protective alleles were reported in Caucasian and only one was found in Asian. There was no common allele to both races. For psoriasis vulgaris, there was no strongly susceptible allele in Caucasian but two in Asian; two strongly protective alleles were found in Caucasian and another two were in Asian. For psoriatic arthritis, two strongly susceptible alleles and one strongly protective allele were reported in Caucasian cases. For psoriasis guttate, only one strongly protective allele was found in Caucasian. In terms of onset age, A*01, A*02, A*03, A*26 and A*30 alleles were more susceptible to type I psoriasis than to type II, and it showed a stronger association in those with family history.

Conclusions

Psoriasis is associated with a number of HLA-A alleles, some are susceptible, some are protective. The association of some alleles is different in terms of different races, clinical types and onset age.