Relationship between the interleukin-6-174 gene and mannose-binding lectin codon 54 gene polymorphisms and condyloma acuminatum
Version of Record online: 3 OCT 2013
© 2013 European Academy of Dermatology and Venereology
Journal of the European Academy of Dermatology and Venereology
Volume 28, Issue 10, pages 1306–1312, October 2014
How to Cite
Aydogan, K., Ozakin, C., Saricaoglu, H., Sigirli, D. and Oral, B. (2014), Relationship between the interleukin-6-174 gene and mannose-binding lectin codon 54 gene polymorphisms and condyloma acuminatum. Journal of the European Academy of Dermatology and Venereology, 28: 1306–1312. doi: 10.1111/jdv.12273
Conflicts of interest
- This report was presented as a poster at the 21st EADV Congress, 27–30 September, Prague, Czech Republic.
- Conflicts of interest
- None declared.
- Funding sources
- None reported.
- Issue online: 24 SEP 2014
- Version of Record online: 3 OCT 2013
- Manuscript Accepted: 14 AUG 2013
- Manuscript Revised: 7 AUG 2013
- Manuscript Received: 25 APR 2013
Several genes encoding different Th1 and Th2 cytokines may play crucial roles in host susceptibility to Condyloma acuminatum (CA). Mannose-binding lectin (MBL) is a serum lectin that mediates complement activation, and it is a member of innate immune system. MBL gene polymorphisms are considered to be associated with several infectious diseases.
In this study, we investigated the association between cytokines and MBL gene polymorphisms with CA.
Forty patients with CA and 40 healthy controls were enrolled in this study. These patients had not responded to at least a therapy modality and all patients had recurrent lesions. Polymorphism of cytokine [Th1 cytokines; tumour necrosis factor-α and interferon (IFN)-γ, Th2 cytokine; IL-6, T regulatory/suppressor cytokines; IL-10 and transforming growth factor-β] genes studies were performed by Polymerase chain reaction sequence-specific primers method and MBL genotyping were studied by PCR-restriction fragment length polymorphism method.
With the aid of agglomerative hierarchical cluster analysis, we categorized subjects into two main clusters (cluster 1; formed by the majority of patients with CA, cluster 2; formed by the majority of healthy controls), which were found to have significantly different distributions of IL-6 and MBL genotypes. Frequencies of IL-6 (-174) G/G (P < 0.001) and MBL AA (P < 0.001) polymorphisms were significantly greater in the cluster 1. In contrast, significantly lower frequencies of the IL-6 G/C (P = 0.046) genotype and MBL AB (P < 0.001) genotype were observed in cluster 1.
These results suggest that the IL-6 G/G and MBL AA gene polymorphisms are potential risk factors and that the IL-6 G/C and MBL AB polymorphisms are a protective factor for occurrence and recurrence of CA.