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jdv12333-sup-0001-FigureS1.jpgimage/jpg1241KFigure S1. The effect of moisturizing treatment on TEWL on volar forearm skin vs. individual baseline values. Panel (a) shows paired values including all patients exposed to the three moisturizers. Panel (b) shows paired values for the three different FLG-genotype groups. Results are presented as before-and-after plots. The red squares represent significant outliers, which are excluded from the statistical analysis using the non-parametric Wilcoxon matched-pair signed-rank test.
jdv12333-sup-0002-FigureS2a.jpgimage/jpg878KFigure S2a. The effect of moisturizing treatment on mRNA expression of fatty acid synthetase (FASN), 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), 3-hydroxy-3-methylglutaryl-CoA synthase (HMGCS1), acetyl-CoA carboxylase beta (ACACΒ), phospholipase A2G2A (PLA2G2A) and serine-palmitoyl-CoA transferase 2 (SPTLC2) relative to baseline values. The results are presented as box plots with the median value as a line across the box, the first quartile value at the bottom, and the third quartile at the top. The whiskers are lines that extend from the bottom and top of the box to the lowest and highest observations respectively. The mean value is shown as (+). Statistical analysis was performed using the non-parametric Wilcoxon signed-rank test.
jdv12333-sup-0003-FigureSb.jpgimage/jpg990KFigure S2b. The effect of moisturizing treatment on mRNA expression of epidermal arachidonate lipoxygenase 3 (ALOXE3), liver X receptor β (LXRB/NR1H2) peroxisome proliferator-activated receptor beta (PPARB) and gamma (PPARG) and β-glucocerebrosidase (GBA) relative to baseline values. For explanations, see Fig. S2a.
jdv12333-sup-0004-FigureSc.jpgimage/jpg1163KFigure S2c. The effect of moisturizing treatment on mRNA expression of CD68, chemokine (C-C motif) ligand 18 (CCL18), Toll-like receptor 4 (TLR4), and interleukin-1 alpha (IL-1a) relative to baseline values. For explanations, see Fig. S2a.

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