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MR-guided laser-induced thermotherapy (LITT) in patients with liver metastases of uveal melanoma

Authors


  • Conflicts of interests

      Conflicts of interests
    • None declared.
  • Funding sources

      Funding sources
    • None declared.

Abstract

Purpose

Evaluation of the local tumour control rate and survival data for magnetic resonance (MR) imaging–guided laser ablation of uveal malignant melanoma liver metastases by using laser-induced interstitial thermotherapy (LITT).

Materials and methods

The LITT was performed in 18 patients with liver metastases (n = 44) from uveal malignant melanoma. All patients tolerated this intervention well. With the Kaplan–Meier method, the survival rates were calculated. Indications for the procedure were defined for patients with no more than five metastases, none of which were larger than 5 cm in diameter: The Indication for LITT treatment were recurrent liver metastases after partial liver resection (22%), locally non-resectable tumours (17%) or metastases in both liver lobes (61%).

Results

The mean survival rate for all treated patients was 3.6 years (95% CI: 2.19, 5.06). We started the calculation on the date of diagnosis of the metastases treated with LITT. The median survival was 1.83 years; 1-year survival, 88%; 3-year survival 47%, 5-year survival 17%. Calculated after the first LITT treatment the median survival was 2.8 years (95% CI: 1.0, 5.0). 10 patients were treated by transarterial chemoembolization before LITT.

Conclusion

MR-guided LITT treatment shows a high local tumour control and survival rates in patients with liver metastases of uveal malignant melanoma.

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