Conflicts of interest
Idiopathic guttate hypomelanosis: an electron microscopy study
Article first published online: 3 AUG 2014
© 2014 European Academy of Dermatology and Venereology
Journal of the European Academy of Dermatology and Venereology
Volume 29, Issue 7, pages 1435–1438, July 2015
How to Cite
Kakepis, M., Havaki, S., Katoulis, A., Katsambas, A., Stavrianeas, N. and Troupis, T.G. (2015), Idiopathic guttate hypomelanosis: an electron microscopy study. Journal of the European Academy of Dermatology and Venereology, 29: 1435–1438. doi: 10.1111/jdv.12646
The authors declare no relevant conflict of interest, pertaining to this manuscript.
- Issue published online: 22 JUN 2015
- Article first published online: 3 AUG 2014
- Manuscript Accepted: 20 JUN 2014
- Manuscript Received: 13 FEB 2014
Few published data, concerning the electron microscopy findings of idiopathic guttate hypomelanosis have been published so far.
To reveal the electron microscopic findings of idiopathic guttate hypomelanosis and their aetiopathogenetic associations.
Punch biopsy specimens from four patients with idiopathic guttate hypomelanosis, after being properly processed, were observed under the electron microscope.
In the epidermis, melanocytes and melanosomes were normal in structure. In some areas, there was a reduced uptake of melanosomes by the keratinocytes. In the dermis, fibroblasts were structurally normal. Also, most elastic and collagen fibres were normal, but there were focal elastotic changes.
No significant structural abnormality of the melanocytes was observed, but rather a functional defect in the transfer of melanosomes from the melanocytes to the keratinocytes.