Co-first authorship Ming-Guang Zhang contributed equally as the co-first author.
Preservative-free 0.9% sodium chloride for flushing and locking peripheral intravenous access device: a prospective controlled trial
Article first published online: 29 NOV 2012
© 2012 Wiley Publishing Asia Pty Ltd and Chinese Cochrane Center, West China Hospital of Sichuan University
Journal of Evidence-Based Medicine
Volume 5, Issue 4, pages 205–208, November 2012
How to Cite
Wang, R., Luo, O., He, L., Li, J.-X. and Zhang, M.-G. (2012), Preservative-free 0.9% sodium chloride for flushing and locking peripheral intravenous access device: a prospective controlled trial. Journal of Evidence-Based Medicine, 5: 205–208. doi: 10.1111/jebm.12004
Funding source Scientific Research Program of Public Health Department of Sichuan Province China (No. 120223).
Conflicts of interest None to declare.
- Issue published online: 29 NOV 2012
- Article first published online: 29 NOV 2012
- Accepted manuscript online: 1 NOV 2012 05:04AM EST
- Received 3 October 2012; accepted for publication 22 October 2012.
- Infusion nursing;
- normal saline;
- heparin saline;
- peripheral intravenous access device
Background and aim: In Mainland China, heparin saline solution is commonly used for flushing and locking peripheral intravenous access devices in clinical practice for a long time. We conducted a prospective controlled trial to compare the effectiveness and safety of preservative-free 0.9% sodium chloride solution versus heparin saline solution as flushing and locking solution for peripheral intravenous access devices.
Methods: Patients with gastroenterological or hepatic diseases were enrolled for this study from August 2011 to October 2011. After non-randomized allocation, preservative-free 0.9% sodium chloride was used as flushing and locking solution in the sodium chloride solution group, while hepatic solution (10 U/mL) was given in the heparin saline solution group. The device related complications and its maintenance duration were compared between two groups. One-way ANOVA, Chi2, or Mantel-Haenszel test were performed using SPSS 13.0 and RevMan 5.0.
Results: Totally, 181 and 178 peripheral intravenous access devices in the sodium chloride solution and heparin saline solution groups were included and analyzed. Results indicated than sodium chloride solution did not increase the risks of occlusion (7.7% vs. 7.9%) and other adverse events of peripheral intravenous access devices (P = 0.163). Sodium chloride solution neither shortened the duration of peripheral intravenous access devices maintenance (3.6 ± 1.1 days vs. 3.7 ± 1.2 days, P = 0.651), nor increased the proportion of abnormal withdrawal (29.3% vs. 31.5%, P = 0.654).
Conclusion: Sodium chloride solution is as effective and safe as conventional heparin saline solution for flushing and locking peripheral intravenous access devices, which results from our evidence-based study and should be transferred to other nurses in China.