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Expression profile of oestrogen receptors and oestrogen-related receptors is organ specific and sex dependent: the Japanese medaka Oryzias latipes model

Authors

  • N. K. M. Cheung,

    1. Department of Biology and Chemistry, City University of Hong Kong, Kowloon, Hong Kong SAR
    2. State Key Laboratory in Marine Pollution, City University of Hong Kong, Kowloon, Hong Kong SAR
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  • A. C. K. Cheung,

    1. Department of Biology and Chemistry, City University of Hong Kong, Kowloon, Hong Kong SAR
    2. State Key Laboratory in Marine Pollution, City University of Hong Kong, Kowloon, Hong Kong SAR
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  • R. R. Ye,

    1. Department of Biology and Chemistry, City University of Hong Kong, Kowloon, Hong Kong SAR
    2. State Key Laboratory in Marine Pollution, City University of Hong Kong, Kowloon, Hong Kong SAR
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  • W. Ge,

    1. State Key Laboratory in Marine Pollution, City University of Hong Kong, Kowloon, Hong Kong SAR
    2. School of Life Sciences, The Chinese University of Hong Kong, New territories, Hong Kong SAR
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  • J. P. Giesy,

    1. Department of Biology and Chemistry, City University of Hong Kong, Kowloon, Hong Kong SAR
    2. Department of Veterinary Biomedical Sciences, Toxicology Centre, Saskatoon, SK, Canada
    3. Department of Zoology and Center for Integrative Toxicology, Michigan State University, East Lansing, MI, U.S.A.
    4. School of Biological Sciences, Kadoorie Biological Sciences Building, The University of Hong Kong, Hong Kong SAR
    5. School of Environment, Nanjing University, Nanjing, Jiangsu, China
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  • D. W. T. Au

    Corresponding author
    1. State Key Laboratory in Marine Pollution, City University of Hong Kong, Kowloon, Hong Kong SAR
    • Department of Biology and Chemistry, City University of Hong Kong, Kowloon, Hong Kong SAR
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Author to whom correspondence should be addressed. Tel.: +852 3442 9710; email: bhdwtau@cityu.edu.hk

Abstract

Gene expression of all known subtypes of oestrogen receptor (ER) and oestrogen-related receptor (ERR) in multiple organs and both sexes of the Japanese medaka Oryzias latipes was profiled and systematically analysed. As revealed by statistical analyses and low-dimensional projections, the expressions of ERRs proved to be organ and sex dependent, which is in contrast with the ubiquitous nature of ERs. Moreover, expressions of specific ERR isoforms (ERRγ1, ERRγ2) were strongly correlated with that of all ERs (ERα, ERβ1 and ERβ2), suggesting the existence of potential interactions. Findings of this study shed light on the co-regulatory role of particular ERRs in oestrogen-ERs signalling and highlight the potential importance of ERRs in determining organ and sex-specific oestrogen responses. Using O. latipes as an alternative vertebrate model, this study provides new directions that call for collective efforts from the scientific community to unravel the mechanistic action of ER-ERR cross-talks, and their intertwining functions, in a cell and sex-specific manner in vivo.

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