Preserved gastric motility in patients with early gastric cancer after endoscopic submucosal dissection
Article first published online: 26 FEB 2013
© 2012 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd
Journal of Gastroenterology and Hepatology
Volume 28, Issue 3, pages 494–498, March 2013
How to Cite
Higuchi, N., Nakamura, K., Ihara, E., Akahoshi, K., Akiho, H., Sumida, Y., Motomura, Y., Kubokawa, M., Ito, T. and Takayanagi, R. (2013), Preserved gastric motility in patients with early gastric cancer after endoscopic submucosal dissection. Journal of Gastroenterology and Hepatology, 28: 494–498. doi: 10.1111/jgh.12086
- Issue published online: 26 FEB 2013
- Article first published online: 26 FEB 2013
- Accepted manuscript online: 7 DEC 2012 07:51AM EST
- Manuscript Accepted: 19 NOV 2012
- 13C-octanoic acid breath test;
- endoscopic submucosal dissection;
- gastric emptying
Background and Aim
Endoscopic submucosal dissection (ESD) is now accepted as a minimally invasive treatment for early gastric cancer (EGC). To our knowledge, however, the functional effects of ESD have not been determined in patients with EGC. We therefore investigated whether gastric motility was affected by ESD.
Using the 13C-octanoic acid breath test, gastric emptying of solid test meals was examined in 26 EGC patients and 18 healthy controls, with EGC patients assayed before and about 2 months after ESD. Based on 13CO2 breath-excretion curves, the lag-phase time (Tlag), half-emptying time (T1/2), and gastric emptying coefficient (GEC) were calculated as indices of gastric emptying.
In healthy controls, the mean Tlag, T1/2, and GEC were 85.5 ± 4.9 min, 148.5 ± 8.0 min, and 3.01 ± 0.09 h, respectively. Before ESD, the mean Tlag, T1/2, and GEC in the EGC patients were 90.1 ± 5.5 min, 174.7 ± 10.4 min, 2.64 ± 0.08 h, respectively. GEC, but not Tlag or T1/2, differed significantly in the two groups, with gastric emptying slower in EGC patients than in controls. Relative to before ESD, the mean Tlag, T1/2, and GEC in EGC patients after ESD were 109.2% ± 7.8%, 107.9% ± 9.6%, 108.4% ± 4.7%, respectively, indicating that ESD did not significantly affect any of these gastric emptying parameters in EGC patients.
ESD is an effective treatment for EGC both in preserving organs and gastric motility.