Potential competing interests: None.
Incidence and clinical characteristics of inflammatory bowel disease in a developed region of Guangdong Province, China: A prospective population-based study
Article first published online: 20 JUN 2013
© 2013 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd
Journal of Gastroenterology and Hepatology
Volume 28, Issue 7, pages 1148–1153, July 2013
How to Cite
Zeng, Z., Zhu, Z., Yang, Y., Ruan, W., Peng, X., Su, Y., Peng, L., Chen, J., Yin, Q., Zhao, C., Zhou, H., Yuan, S., Hao, Y., Qian, J., Ng, S. C., Chen, M. and Hu, P. (2013), Incidence and clinical characteristics of inflammatory bowel disease in a developed region of Guangdong Province, China: A prospective population-based study. Journal of Gastroenterology and Hepatology, 28: 1148–1153. doi: 10.1111/jgh.12164
These authors contributed equally to this work.
- Issue published online: 20 JUN 2013
- Article first published online: 20 JUN 2013
- Accepted manuscript online: 22 FEB 2013 10:03AM EST
- Manuscript Accepted: 4 FEB 2013
- Health Research and Special Projects Grant. Grant Number: 201002020
- Clinical Key Technology Program Grant from Ministry of Health of China
- Crohn's disease;
- Guangdong Province;
- inflammatory bowel disease;
- ulcerative colitis
Background and Aims
The incidence of inflammatory bowel disease (IBD) is increasing in China with urbanization and socioeconomic development. There is however a lack of prospective, population-based epidemiology study on IBD in China. The aim of the study is to define the incidence and clinical characteristics of IBD in a developed region of Guangdong Province in China.
A prospective, population-based incidence study was conducted from July 2011 to June 2012 in Zhongshan, Guangdong, China. All newly diagnosed IBD cases in Zhongshan were included.
In total, 48 new cases of IBD (17 Crohn's disease [CD]; 31 ulcerative colitis [UC]) were identified over a 1-year period from July 2011. Age-standardized incidence rates for IBD, UC, and CD were 3.14, 2.05, and 1.09 per 100 000 persons, respectively. The median age of UC was 38, and that of CD was 25. Terminal ileum involvement only (L1), isolated colonic disease (L2), and ileocolonic disease (L3) were reported in 24%, 6%, and 71% of patients with CD, respectively. Twenty-four percent of patients had coexisting upper gastrointestinal disease (L4). Inflammatory (B1), stricturing (B2), and penetrating (B3) behavior were seen in 65%, 24%, and 12% of CD patients, respectively. Fifty-nine percent of CD and 26% of UC patients had extra-intestinal manifestations.
This is the first prospective, population-based IBD epidemiological study in a developed region of China. The incidence of IBD is similar to that in Japan and Hong Kong but lower than that in South Korea and Western countries.