Author Disclosures: No author had any disclosures to make relevant to this manuscript.
Toll-like receptors in hepatitis C infection: Implications for pathogenesis and treatment
Article first published online: 25 APR 2013
© 2013 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd
Journal of Gastroenterology and Hepatology
Volume 28, Issue 5, pages 766–776, May 2013
How to Cite
Howell, J., Angus, P., Gow, P. and Visvanathan, K. (2013), Toll-like receptors in hepatitis C infection: Implications for pathogenesis and treatment. Journal of Gastroenterology and Hepatology, 28: 766–776. doi: 10.1111/jgh.12170
Grant Support: Dr Jessica Howell received scholarship funds for stipend from the Gastroenterological Society of Australia (GESA).
- Issue published online: 25 APR 2013
- Article first published online: 25 APR 2013
- Accepted manuscript online: 22 FEB 2013 10:03AM EST
- Manuscript Accepted: 3 FEB 2013
- Gastroenterological Society of Australia (GESA)
- cell and molecular biology;
- liver immunobiology;
- viral hepatitis
Hepatitis C virus (HCV) infection is a significant global health problem, affecting over 150 million people worldwide. While the critical role of the adaptive immune system in HCV infection is well-established, the importance of the innate immune system in HCV infection has only been recognized in more recent years. Toll-like receptors form the cornerstone of the innate immune response, and there is considerable evidence for their crucial role in hepatitis C infection. This review outlines recent advances made in our understanding of the role of Toll-like receptor function in HCV infection, exploring how HCV manipulates host immunity to evade immune clearance and establish persistent infection despite leading to inflammatory hepatic damage.